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Solid lipid nanoparticles loaded with curcumin: development and in vitro toxicity against CT26 cells.
Ganassin, Rayane; da Silva, Victor Carlos Mello; Araujo, Victor Hugo Sousa; Tavares, Giulia Rosa; da Silva, Patrícia Bento; Cáceres-Vélez, Paolin Rocio; Porcel, Joaquin E Martínez; Rodrigues, Mosar Corrêa; Andreozzi, Patrizia; Fernandes, Richard Perosa; Fonseca-Santos, Bruno; Moya, Sergio; Azevedo, Ricardo Bentes; Chorilli, Marlus; Muehlmann, Luis Alexandre.
Afiliação
  • Ganassin R; Laboratory of Nanoscience & Immunology, Faculty of Ceilandia, University of Brasilia, Brasilia/DF, 72220-900, Brazil.
  • da Silva VCM; Department of Genetics & Morphology, Institute of Biological Sciences, University of Brasilia, Brasilia, 70910-900, Brazil.
  • Araujo VHS; Laboratory of Nanoscience & Immunology, Faculty of Ceilandia, University of Brasilia, Brasilia/DF, 72220-900, Brazil.
  • Tavares GR; Department of Genetics & Morphology, Institute of Biological Sciences, University of Brasilia, Brasilia, 70910-900, Brazil.
  • da Silva PB; Laboratory of Nanoscience & Immunology, Faculty of Ceilandia, University of Brasilia, Brasilia/DF, 72220-900, Brazil.
  • Cáceres-Vélez PR; Department of Genetics & Morphology, Institute of Biological Sciences, University of Brasilia, Brasilia, 70910-900, Brazil.
  • Porcel JEM; Laboratory of Nanoscience & Immunology, Faculty of Ceilandia, University of Brasilia, Brasilia/DF, 72220-900, Brazil.
  • Rodrigues MC; Department of Genetics & Morphology, Institute of Biological Sciences, University of Brasilia, Brasilia, 70910-900, Brazil.
  • Andreozzi P; Department of Genetics & Morphology, Institute of Biological Sciences, University of Brasilia, Brasilia, 70910-900, Brazil.
  • Fernandes RP; Department of Genetics & Morphology, Institute of Biological Sciences, University of Brasilia, Brasilia, 70910-900, Brazil.
  • Fonseca-Santos B; Soft Matter Laboratory, Center for Cooperative Research in Biomaterials (CIC biomaGUNE), San Sebastian, Spain.
  • Moya S; School of Biosciences, The University of Melbourne, Parkville, VIC 3010, Australia.
  • Azevedo RB; Soft Matter Laboratory, Center for Cooperative Research in Biomaterials (CIC biomaGUNE), San Sebastian, Spain.
  • Chorilli M; Laboratory of Nanoscience & Immunology, Faculty of Ceilandia, University of Brasilia, Brasilia/DF, 72220-900, Brazil.
  • Muehlmann LA; Department of Genetics & Morphology, Institute of Biological Sciences, University of Brasilia, Brasilia, 70910-900, Brazil.
Nanomedicine (Lond) ; 17(3): 167-179, 2022 02.
Article em En | MEDLINE | ID: mdl-35048742
Aim: To develop a new curcumin carrier consisting of murumuru butter nanoparticles (SLN-Cs). Methods: A phase-inversion temperature method was used to produce SLN-Cs. The interaction of SLN-Cs with murine colon adenocarcinoma (CT26) cells in vitro was analyzed by confocal microscopy. Results: Stable SLN-Cs with a high curcumin-loading capacity were obtained. The SLN-Cs were more toxic to CT26 than free curcumin. Fluorescence microscopy images showed the SLN-Cs to be taken up by CT26 cells in vitro. Conclusion: These results indicate that SLN-Cs are suitable carriers of curcumin in aqueous media.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Curcumina / Nanopartículas Limite: Animals Idioma: En Revista: Nanomedicine (Lond) Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Curcumina / Nanopartículas Limite: Animals Idioma: En Revista: Nanomedicine (Lond) Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido