[Effect of intratumor macrophages on the growth of a rat sarcoma]. / Influencia de los macrófagos intratumorales en el crecimiento de un sarcoma de rata.
Rev Argent Microbiol
; 19(2): 55-63, 1987.
Article
em Es
| MEDLINE
| ID: mdl-3503311
The removal of active phagocytic cells (CFA) from suspensions of a rat sarcoma (S-E 100) caused a decrease in tumor development in "m" line rats; consequently, we postulated that the macrophage (M phi) population infiltrating the tumor might possess inhibitory functions. In the present paper we investigate whether the effect of CFA is a general one or whether it is dependent on the interaction between M phi infiltrating the tumor and the recipient. S-E 100 was inoculated in "m" line rats (S-E 100,m) and in "c" (S-E 100,c); CFA were depleted from both tumoral suspensions with carbonyl iron powder (FeC), inoculating the supernatant tumor sells denominated S.FeC-m and S.FeC-c, and the corresponding control suspensions, S Te-m and S Te-c. Inocula for both recipients were subcutaneous and contained 1 x 10(6) cells. The elimination of CFA induced a decrease in the development of the tumor in "m" recipients only when the inoculum was provided by S-E 100, m (Table 1). On the contrary no change in tumor growth was detected in the "C" recipients, whether the inoculum was provided by SE-100, m or by S-E 100, c (Table 1). An inhibitory effect on the immune response exerted by M phi infiltrating S-E 100, as a non general effect, is postulated. This effect was obtained only when intratumoral M phi were syngeneic with the recipient and specifically for "m" line.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sarcoma Experimental
/
Macrófagos
Limite:
Animals
Idioma:
Es
Revista:
Rev Argent Microbiol
Ano de publicação:
1987
Tipo de documento:
Article
País de afiliação:
Argentina
País de publicação:
Argentina