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High-intensity interval resistance training (HIIRT) improves liver gluconeogenesis from lactate in Swiss mice.
Muller, Gabrielle Yasmin; Matos, Felipe de Oliveira; Perego Junior, Julio Ernesto; Kurauti, Mirian Ayumi; Diaz Pedrosa, Maria Montserrat.
Afiliação
  • Muller GY; Program of Graduate Studies in Physiological Sciences, Center of Biological Sciences, State University of Maringa - UEM, Maringa, PR, Brazil.
  • Matos FO; Department of Human Movement Sciences, Center of Health Sciences, State University of Maringa - UEM, Ivaipora, PR, Brazil.
  • Perego Junior JE; Program of Graduate Studies in Physiological Sciences, Center of Biological Sciences, State University of Maringa - UEM, Maringa, PR, Brazil.
  • Kurauti MA; Department of Physiological Sciences, Center of Biological Sciences, State University of Maringa - UEM, Maringa, PR, Brazil.
  • Diaz Pedrosa MM; Department of Physiological Sciences, Center of Biological Sciences, State University of Maringa - UEM, Maringa, PR, Brazil.
Appl Physiol Nutr Metab ; 47(4): 439-446, 2022 Apr.
Article em En | MEDLINE | ID: mdl-35020517
High-intensity physical exercise favors anaerobic glycolysis and increases lactatemia. Lactate is converted back to glucose in the liver, so that the lactate threshold, an indicator of physical performance, must be related to the gluconeogenic capacity of the liver. This research assessed the effect of a high-intensity interval resistance training (HIIRT) on liver gluconeogenesis from lactate. Swiss mice were trained (groups T) on vertical ladder with overload of 90% of their maximal load. Control animals remained untrained (groups C0 and C8). In situ liver perfusion with lactate and adrenaline was performed in rested mice after 6 hours of food deprivation. There were larger outputs of glucose (T6, 71.90%; T8, 54.53%) and pyruvate (T8, 129.28%) (representative values for 4 mM lactate) in the groups trained for 6 or 8 weeks (T6 and T8), and of glucose in the presence of adrenaline in group T8 (280%). The content of PEPCK, an important regulatory enzyme of the gluconeogenic pathway, was 69.13% higher in group T8 than in the age-matched untrained animals (C8). HIIRT augmented liver gluconeogenesis from lactate and this might improve the lactate threshold. Novelty: The liver metabolizes lactate from muscle into glucose. Physical training may enhance the gluconeogenic capacity of the liver. As lactate clearance by the liver improves, lactate threshold is displaced to higher exercise intensities.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Treinamento Resistido / Gluconeogênese Limite: Animals / Humans Idioma: En Revista: Appl Physiol Nutr Metab Assunto da revista: CIENCIAS DA NUTRICAO / FISIOLOGIA / MEDICINA ESPORTIVA / METABOLISMO Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Canadá

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Treinamento Resistido / Gluconeogênese Limite: Animals / Humans Idioma: En Revista: Appl Physiol Nutr Metab Assunto da revista: CIENCIAS DA NUTRICAO / FISIOLOGIA / MEDICINA ESPORTIVA / METABOLISMO Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Canadá