Physical Exercise and Liver Autophagy: Potential Roles of IL-6 and Irisin.

Pinto, Ana P; Ropelle, Eduardo R; Quadrilatero, Joe; da Silva, Adelino S R

Pinto, Ana P; Ropelle, Eduardo R; Quadrilatero, Joe; da Silva, Adelino S R.

Afiliação

Pinto AP; Postgraduate Program in Rehabilitation and Functional Performance, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto São Paulo, Brazil.
Ropelle ER; Laboratory of Molecular Biology of Exercise, School of Applied Sciences, University of Campinas, Limeira, São Paulo, Brazil.
Quadrilatero J; Department of Kinesiology, University of Waterloo, Waterloo, ON, Canada.

Exerc Sport Sci Rev ; 50(2): 89-96, 2022 04 01.

Article em En | MEDLINE | ID: mdl-34961755

RESUMO

Autophagic dysregulation contributes to liver diseases. Although some investigations have examined the effects of endurance and resistance exercise on autophagy activation, potential myokines responsible for skeletal muscle-liver crosstalk are still unknown. Based on experimental studies and bioinformatics, we hypothesized that interleukin 6 (IL-6) and irisin might be key players in the contraction-induced release of molecules that regulate liver autophagic responses.

Assuntos

Autofagia; Exercício Físico; Fibronectinas; Interleucina-6; Fígado; Fibronectinas/fisiologia; Humanos; Interleucina-6/fisiologia; Músculo Esquelético

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Autofagia / Exercício Físico / Fibronectinas / Interleucina-6 / Fígado Limite: Humans Idioma: En Revista: Exerc Sport Sci Rev Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos

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