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Strain-, Sex-, and Time-Dependent Antidepressant-like Effects of Cannabidiol.
Silote, Gabriela P; Gatto, Michelle C; Eskelund, Amanda; Guimarães, Francisco S; Wegener, Gregers; Joca, Sâmia R L.
Afiliação
  • Silote GP; Department of Biomolecular Sciences, School of Pharmaceutical Sciences of Ribeirão Preto (FCFRP), University of São Paulo (USP), Ribeirão Preto 14040-903, SP, Brazil.
  • Gatto MC; Translational Neuropsychiatry Unit (TNU), Department of Clinical Medicine, Aarhus University, 8000 Aarhus, Denmark.
  • Eskelund A; Department of Biomolecular Sciences, School of Pharmaceutical Sciences of Ribeirão Preto (FCFRP), University of São Paulo (USP), Ribeirão Preto 14040-903, SP, Brazil.
  • Guimarães FS; Translational Neuropsychiatry Unit (TNU), Department of Clinical Medicine, Aarhus University, 8000 Aarhus, Denmark.
  • Wegener G; Department of Pharmacology, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto 14049-900, SP, Brazil.
  • Joca SRL; Center for Interdisciplinary Research on Applied Neurosciences (NAPNA), University of São Paulo, São Paulo 05508-000, SP, Brazil.
Pharmaceuticals (Basel) ; 14(12)2021 Dec 06.
Article em En | MEDLINE | ID: mdl-34959670
Cannabidiol (CBD) is a non-intoxicating compound extracted from Cannabis sativa, showing antidepressant-like effects in different rodent models. However, inconsistent results have been described depending on the species and the strain used to assess depressive-like behavior. Moreover, only a few studies investigated the effect of CBD in female rodents. Therefore, we aimed to (i) investigate the effects of CBD in two different strains of mice (Swiss and C57BL/6) and a rat model of depression based on selective breeding (Flinders Sensitive and Resistant Lines, FSL and FRL) subjected to tests predictive of antidepressant-like effects and (ii) investigate the influence of sex in the effects of CBD in both mice and rats. CBD induced an antidepressant-like effect in male Swiss but not in female Swiss or C57BL/6 mice in the tail suspension test (TST). In male FSL rats, CBD produced an antidepressant-like effect 1 h post injection. However, in female FSL, CBD induced a bimodal effect, increasing the immobility time at 1 h and decreasing it at 2 h. In conclusion, strain, sex, and administration time affect CBD's behavioral response to rodents exposed to tests predictive of antidepressant effects.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Revista: Pharmaceuticals (Basel) Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Revista: Pharmaceuticals (Basel) Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça