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MicroRNAs Regulating Renin-Angiotensin-Aldosterone System, Sympathetic Nervous System and Left Ventricular Hypertrophy in Systemic Arterial Hypertension.
Improta-Caria, Alex Cleber; Aras, Marcela Gordilho; Nascimento, Luca; De Sousa, Ricardo Augusto Leoni; Aras-Júnior, Roque; Souza, Bruno Solano de Freitas.
Afiliação
  • Improta-Caria AC; Post-Graduate Program in Medicine and Health, Faculty of Medicine, Federal University of Bahia, Salvador 40110-100, Brazil.
  • Aras MG; Department of Physical Education in Cardiology of the State of Bahia, Brazilian Society of Cardiology, Salvador 41170-130, Brazil.
  • Nascimento L; Center for Biotechnology and Cell Therapy, São Rafael Hospital, Salvador 41253-190, Brazil.
  • De Sousa RAL; Faculty of Medicine, Federal University of Bahia, Salvador 40110-100, Brazil.
  • Aras-Júnior R; Faculty of Medicine, Federal University of Bahia, Salvador 40110-100, Brazil.
  • Souza BSF; Neuroscience and Exercise Group, UFVJM, Diamantina 39000-000, Brazil.
Biomolecules ; 11(12)2021 11 26.
Article em En | MEDLINE | ID: mdl-34944415
MicroRNAs are small non-coding RNAs that regulate gene and protein expression. MicroRNAs also regulate several cellular processes such as proliferation, differentiation, cell cycle, apoptosis, among others. In this context, they play important roles in the human body and in the pathogenesis of diseases such as cancer, diabetes, obesity and hypertension. In hypertension, microRNAs act on the renin-angiotensin-aldosterone system, sympathetic nervous system and left ventricular hypertrophy, however the signaling pathways that interact in these processes and are regulated by microRNAs inducing hypertension and the worsening of the disease still need to be elucidated. Thus, the aim of this review is to analyze the pattern of expression of microRNAs in these processes and the possible associated signaling pathways.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hipertrofia Ventricular Esquerda / MicroRNAs / Hipertensão Limite: Humans Idioma: En Revista: Biomolecules Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hipertrofia Ventricular Esquerda / MicroRNAs / Hipertensão Limite: Humans Idioma: En Revista: Biomolecules Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça