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Metabolites from Induratia spp. modulating key enzymes in human hemostasis.
Cardoso, Mauro Guilherme Barros; Trento, Marcus Vinicius Cardoso; Cesar, Pedro Henrique Souza; Marcussi, Silvana; Cardoso, Patrícia Gomes.
Afiliação
  • Cardoso MGB; Department of Biology, Universidade Federal de Lavras, Lavras, MG, Brazil.
  • Trento MVC; Department of Chemistry, Universidade Federal de Lavras, Lavras, MG, Brazil.
  • Cesar PHS; Department of Chemistry, Universidade Federal de Lavras, Lavras, MG, Brazil.
  • Marcussi S; Department of Chemistry, Universidade Federal de Lavras, Lavras, MG, Brazil.
  • Cardoso PG; Department of Biology, Universidade Federal de Lavras, Lavras, MG, Brazil. patricia@ufla.br.
Arch Microbiol ; 204(1): 27, 2021 Dec 18.
Article em En | MEDLINE | ID: mdl-34921623
Induratia spp. fungi have been poorly evaluated for their non-volatile secondary metabolites. In the present work, we evaluated the effects of non-volatile secondary metabolites released into the culture medium by Induratia spp. upon toxic alterations induced by Bothrops spp. venoms. B. atrox venom phospholipase was inhibited by Induratia spp. around 12 and 16%. The extracts of the two strains inhibited 12-25% of the hemolysis induced by B.moojeni venom. Thrombolysis was inhibited by 30-60% by the compounds present in both extracts. The coagulation induced by B. moojeni venom was prolonged by 26-41 s by the action of the extracts of I. coffeana. The fungal extracts did not exert any cytotoxic effect, nor did they induce any alteration in the other evaluated substrates show the potential use of non-volatile metabolites produced by the fungi evaluated as enzyme modulators, especially for proteases with a fundamental role in human hemostasis.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peptídeo Hidrolases / Endopeptidases / Xylariales / Hemostasia Limite: Animals / Humans Idioma: En Revista: Arch Microbiol Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Alemanha
Texto completo
Adicionar na Minha BVS
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XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peptídeo Hidrolases / Endopeptidases / Xylariales / Hemostasia Limite: Animals / Humans Idioma: En Revista: Arch Microbiol Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Alemanha