Caerulines A and B, Flavonol Diacylglycosides from Persea caerulea.
ACS Omega
; 6(48): 32631-32636, 2021 Dec 07.
Article
em En
| MEDLINE
| ID: mdl-34901611
Two undescribed 4'-O-methylkaempferol-[3â³,4â³-di-p-coumaroyl]-α-l-rhamnopyranosides, caerulines A and B (1-2), along with three known 4'-O-methylkaempferol diacylrhamnosides isomers (3-5) were isolated from an ethanol extract of the leaves of Persea caerulea, a native plant growing on the Colombian Caribbean coast. The chemical structures of 1 and 2 were elucidated by spectroscopic methods. The effect of compounds 1-5 against four pathogenic microorganisms [i.e., methicillin-resistant Staphylococcus aureus (MRSA), Acinetobacter baumannii, Candida albicans, and Aspergillus fumigatus] was tested in vitro. The compounds exhibited no activity against these pathogens except MRSA (MIC 12-48 µg/mL). Caeruline B (2) was found to be the most active compound with a modest anti-MRSA activity (MIC = 12 µg/mL).
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
ACS Omega
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Colômbia
País de publicação:
Estados Unidos