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Maternal consumption of É·3 attenuates metabolic disruption elicited by saturated fatty acids-enriched diet in offspring rats.
Alves-de-Oliveira, Debora S; Bloise, Aline M N L G; Silva, Laura M L; Rocha-Junior, Reginaldo L; Lima-Júnior, Nelson C; Menezes, Luiza G S; Silva, Elionay G S; De Oliveira, Yohanna; Wanderley, Almir G; de-Brito-Alves, José L; Souza, Viviane O N; Costa-Silva, João H.
Afiliação
  • Alves-de-Oliveira DS; Laboratory of Nutrition, Physical Activity and Phenotypic Plasticity, Department of Physical Education and Sport Sciences, Universidade Federal de Pernambuco, UFPE, Vitória de Santo Antão, PE, 55608-680, Brazil.
  • Bloise AMNLG; Laboratory of Nutrition, Physical Activity and Phenotypic Plasticity, Department of Physical Education and Sport Sciences, Universidade Federal de Pernambuco, UFPE, Vitória de Santo Antão, PE, 55608-680, Brazil.
  • Silva LML; Laboratory of Nutrition, Physical Activity and Phenotypic Plasticity, Department of Physical Education and Sport Sciences, Universidade Federal de Pernambuco, UFPE, Vitória de Santo Antão, PE, 55608-680, Brazil.
  • Rocha-Junior RL; Laboratory of Nutrition, Physical Activity and Phenotypic Plasticity, Department of Physical Education and Sport Sciences, Universidade Federal de Pernambuco, UFPE, Vitória de Santo Antão, PE, 55608-680, Brazil.
  • Lima-Júnior NC; Laboratory of Nutrition, Physical Activity and Phenotypic Plasticity, Department of Physical Education and Sport Sciences, Universidade Federal de Pernambuco, UFPE, Vitória de Santo Antão, PE, 55608-680, Brazil.
  • Menezes LGS; Laboratory of Nutrition, Physical Activity and Phenotypic Plasticity, Department of Physical Education and Sport Sciences, Universidade Federal de Pernambuco, UFPE, Vitória de Santo Antão, PE, 55608-680, Brazil.
  • Silva EGS; Laboratory of Nutrition, Physical Activity and Phenotypic Plasticity, Department of Physical Education and Sport Sciences, Universidade Federal de Pernambuco, UFPE, Vitória de Santo Antão, PE, 55608-680, Brazil.
  • De Oliveira Y; Department of Nutrition, Universidade Federal da Paraíba, UFPB, João Pessoa, PB, 58051-900, Brazil.
  • Wanderley AG; Department of Physiology and Pharmacology, Universidade Federal de Pernambuco, UFPE, Recife, PE, 50760-901, Brazil.
  • de-Brito-Alves JL; Department of Nutrition, Universidade Federal da Paraíba, UFPB, João Pessoa, PB, 58051-900, Brazil.
  • Souza VON; Laboratory of Nutrition, Physical Activity and Phenotypic Plasticity, Department of Physical Education and Sport Sciences, Universidade Federal de Pernambuco, UFPE, Vitória de Santo Antão, PE, 55608-680, Brazil.
  • Costa-Silva JH; Laboratory of Nutrition, Physical Activity and Phenotypic Plasticity, Department of Physical Education and Sport Sciences, Universidade Federal de Pernambuco, UFPE, Vitória de Santo Antão, PE, 55608-680, Brazil. Electronic address: joao.hcsilva@ufpe.br.
Nutr Metab Cardiovasc Dis ; 32(1): 279-289, 2022 01.
Article em En | MEDLINE | ID: mdl-34893407
BACKGROUND AND AIMS: High-fat diet (HFD) intake during gestation and lactation has been associated with an increased risk of developing cardiometabolic disorders in adult offspring. We investigated whether metabolic alterations resulting from the maternal consumption of HFD are prevented by the addition of omega-3 (É·3) in the diet. METHODS AND RESULTS: Wistar rat dams were fed a control (C: 19% of lipids and É·6:É·3 = 12), HF (HF: 33% lipids and É·6:É·3 = 21), or HF enriched with É·3 (HFω3: 33% lipids and É·6:É·3 = 9) diet during gestation and lactation, and their offspring food consumption, murinometric measurements, serum levels of metabolic markers, insulin and pyruvate sensitivity tests were evaluated. The maternal HFD increased body weight at birth, dyslipidemia, and elevated fasting glucose levels in the HF group. The enrichment of É·3 in the maternal HFD led to lower birth weight and improved lipid, glycemic, and transaminase biochemical profile of the HFω3 group until the beginning of adulthood. However, at later adulthood of the offspring, there was no improvement in these biochemical parameters. CONCLUSION: Our findings show the maternal consumption of high-fat É·3-rich diet is able to attenuate or prevent metabolic disruption elicited by HFD in offspring until 90 days old, but not in the long term, as observed at 300 days old of the offspring.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Efeitos Tardios da Exposição Pré-Natal / Ácidos Graxos Ômega-3 Tipo de estudo: Etiology_studies Limite: Animals / Female / Humans Idioma: En Revista: Nutr Metab Cardiovasc Dis Assunto da revista: ANGIOLOGIA / CARDIOLOGIA / CIENCIAS DA NUTRICAO / METABOLISMO Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Efeitos Tardios da Exposição Pré-Natal / Ácidos Graxos Ômega-3 Tipo de estudo: Etiology_studies Limite: Animals / Female / Humans Idioma: En Revista: Nutr Metab Cardiovasc Dis Assunto da revista: ANGIOLOGIA / CARDIOLOGIA / CIENCIAS DA NUTRICAO / METABOLISMO Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda