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Antioxidant Activity, Molecular Docking, Quantum Studies and In Vivo Antinociceptive Activity of Sulfonamides Derived From Carvacrol.
de Oliveira, Aldo S; Llanes, Luana C; Nunes, Ricardo J; Nucci-Martins, Catharina; de Souza, Anacleto S; Palomino-Salcedo, David L; Dávila-Rodríguez, María J; Ferreira, Leonardo L G; Santos, Adair R S; Andricopulo, Adriano D.
Afiliação
  • de Oliveira AS; Department of Exact Sciences and Education, Federal University of Santa Catarina-UFSC, Blumenau, Brazil.
  • Llanes LC; Laboratory of Medicinal and Computational Chemistry, Institute of Physics of São Carlos, University of São Paulo-USP, São Carlos, Brazil.
  • Nunes RJ; Department of Chemistry and Biochemistry, University of California, Santa Barbara, Santa Barbara, CA, United States.
  • Nucci-Martins C; Departament of Chemistry, Federal University of Santa Catarina-UFSC, Florianópolis, Brazil.
  • de Souza AS; Department of Physiological Sciences, Center of Biological Sciences, Federal University of Santa Catarina-UFSC, Florianópolis, Brazil.
  • Palomino-Salcedo DL; Department of Structural and Functional Biology, Institute of Biology, University of Campinas-UNICAMP, Campinas, Brazil.
  • Dávila-Rodríguez MJ; Laboratory of Medicinal and Computational Chemistry, Institute of Physics of São Carlos, University of São Paulo-USP, São Carlos, Brazil.
  • Ferreira LLG; Laboratory of Medicinal and Computational Chemistry, Institute of Physics of São Carlos, University of São Paulo-USP, São Carlos, Brazil.
  • Santos ARS; Department of Chemistry, Federal University of São Carlos-UFSCar, São Carlos, Brazil.
  • Andricopulo AD; Laboratory of Medicinal and Computational Chemistry, Institute of Physics of São Carlos, University of São Paulo-USP, São Carlos, Brazil.
Front Pharmacol ; 12: 788850, 2021.
Article em En | MEDLINE | ID: mdl-34887769
The synthesis and antioxidant, antinociceptive and antiedematogenic activities of sulfonamides derived from carvacrol-a druglike natural product-are reported. The compounds showed promising antioxidant activity, and sulfonamide derived from morpholine (S1) demonstrated excellent antinociceptive and antiedematogenic activities, with no sedation or motor impairment. The mechanism that underlies the carvacrol and derived sulfonamides' relieving effects on pain has not yet been fully elucidated, however, this study shows that the antinociceptive activity can be partially mediated by the antagonism of glutamatergic signaling. Compound S1 presented promising efficacy and was predicted to have an appropriate medicinal chemistry profile. Thus, derivative S1 is an interesting starting point for the design of new leads for the treatment of pain and associated inflammation and prooxidative conditions.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Revista: Front Pharmacol Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Revista: Front Pharmacol Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça