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Differentiating Diabetic Ketoacidosis and Hyperglycemic Ketosis Due to Cannabis Hyperemesis Syndrome in Adults With Type 1 Diabetes.
Akturk, Halis Kaan; Snell-Bergeon, Janet; Kinney, Gregory L; Champakanath, Anagha; Monte, Andrew; Shah, Viral N.
Afiliação
  • Akturk HK; Barbara Davis Center for Diabetes, University of Colorado, Aurora, CO.
  • Snell-Bergeon J; Barbara Davis Center for Diabetes, University of Colorado, Aurora, CO.
  • Kinney GL; Department of Epidemiology, University of Colorado, Aurora, CO.
  • Champakanath A; Barbara Davis Center for Diabetes, University of Colorado, Aurora, CO.
  • Monte A; Department of Emergency Medicine, University of Colorado, Aurora, CO.
  • Shah VN; Barbara Davis Center for Diabetes, University of Colorado, Aurora, CO.
Diabetes Care ; 45(2): 481-483, 2022 02 01.
Article em En | MEDLINE | ID: mdl-34880067
OBJECTIVE: To differentiate diabetic ketoacidosis (DKA) from hyperglycemic ketosis due to cannabis hyperemesis syndrome (HK-CHS) in adults with type 1 diabetes. RESEARCH DESIGN AND METHODS: Of 295 adults with type 1 diabetes who were seen with DKA-related ICD-10 codes, 68 patients with 172 DKA events meeting the inclusion criteria were analyzed. Cannabis use was defined as a positive urine test result for cannabis. Linear mixed models were used to define HK-CHS (pH ≥7.4 with bicarbonate ≥15 mmol/L [mEq/L]), and sensitivity and specificity were calculated using the receiver operating characteristic (ROC) curve. RESULTS: Cannabis users had significantly higher pH (7.42 ± 0.01 vs. 7.09 ± 0.02) and bicarbonate (19.2 ± 0.61 vs. 9.1 ± 0.71 mmol/L) (P < 0.0001) compared with nonusers. The area under the ROC curve for a positive cannabis urine test result predicting HK-CHS was 0.9892. CONCLUSIONS: In patients who present with DKA and higher pH, especially pH ≥7.4, cannabis use should be considered in the differential diagnosis.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cannabis / Cetoacidose Diabética / Diabetes Mellitus Tipo 1 / Cetose Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Adult / Humans Idioma: En Revista: Diabetes Care Ano de publicação: 2022 Tipo de documento: Article País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cannabis / Cetoacidose Diabética / Diabetes Mellitus Tipo 1 / Cetose Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Adult / Humans Idioma: En Revista: Diabetes Care Ano de publicação: 2022 Tipo de documento: Article País de publicação: Estados Unidos