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Restraint stress potentiates neuropeptide Y-mediated impairment on spatial memory in rats.
Soares, Ericks Sousa; Vanz, Felipe; Linartevichi, Vagner Fagnani; Cimarosti, Helena; de Lima, Thereza Christina Monteiro.
Afiliação
  • Soares ES; Pharmacology Department, Centre for Biological Sciences, Federal University of Santa Catarina, 88040-900 Florianopolis, Brazil.
  • Vanz F; Pharmacology Department, Centre for Biological Sciences, Federal University of Santa Catarina, 88040-900 Florianopolis, Brazil; University of the West of Santa Catarina, 89566-252 Videira, Brazil.
  • Linartevichi VF; University Centre Assis Gurgacz, 85806-095 Cascavel, Brazil.
  • Cimarosti H; Pharmacology Department, Centre for Biological Sciences, Federal University of Santa Catarina, 88040-900 Florianopolis, Brazil. Electronic address: helena.cimarosti@ufsc.br.
  • de Lima TCM; Pharmacology Department, Centre for Biological Sciences, Federal University of Santa Catarina, 88040-900 Florianopolis, Brazil. Electronic address: thereza.lima@ufsc.br.
Behav Brain Res ; 419: 113705, 2022 02 15.
Article em En | MEDLINE | ID: mdl-34871704
Memory is the ability to store, retrieve and use information that requires a progressive time-dependent stabilization process known as consolidation to be established. The hippocampus is essential for processing all the information that forms memory, especially spatial memory. Neuropeptide Y (NPY) affects memory, so in this study we investigated the participation and recruitment of NPY receptors during spatial memory consolidation in rats. Using the water maze test, we show that NPY (1 pmol) injected into the dorsal hippocampus impaired memory consolidation and that previous restraint stress (30 min) potentiates NPY effects, i.e. further impaired memory consolidation. Using selective antagonists for NPY Y1 and Y2 receptors we demonstrate that both receptors play a key role on spatial memory consolidation. Our data suggest that NPY modulates aversive and adaptive memory formation by NPY receptors activation.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Estresse Psicológico / Comportamento Animal / Neuropeptídeo Y / Receptores de Neuropeptídeo Y / Memória Espacial / Transtornos da Memória Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Behav Brain Res Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Estresse Psicológico / Comportamento Animal / Neuropeptídeo Y / Receptores de Neuropeptídeo Y / Memória Espacial / Transtornos da Memória Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Behav Brain Res Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda