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Low Mg content on Ti-Nb-Sn alloy when in contact with eBMMSCs promotes improvement of its biological functions.
da Silva Dias, Carolina; Rossi, Mariana Correa; Apolonio, Emanuel V P; Dos Santos Rosa, Gustavo; Pfeifer, João Pedro Hübbe; Hussni, Carlos Alberto; Watanabe, Marcos Jun; Alves, Ana Liz Garcia.
Afiliação
  • da Silva Dias C; Department of Veterinary Surgery and Anesthesiology, São Paulo State University - Júlio de Mesquita Filho Unesp Prof. Doutor Walter Mauricio Correa St., n/n, Botucatu, SP, ZIP- 18618-681, Brazil.
  • Rossi MC; Department of Veterinary Surgery and Anesthesiology, São Paulo State University - Júlio de Mesquita Filho Unesp Prof. Doutor Walter Mauricio Correa St., n/n, Botucatu, SP, ZIP- 18618-681, Brazil. mrncorrea90@gmail.com.
  • Apolonio EVP; Department of Veterinary Surgery and Anesthesiology, São Paulo State University - Júlio de Mesquita Filho Unesp Prof. Doutor Walter Mauricio Correa St., n/n, Botucatu, SP, ZIP- 18618-681, Brazil.
  • Dos Santos Rosa G; Department of Veterinary Surgery and Anesthesiology, São Paulo State University - Júlio de Mesquita Filho Unesp Prof. Doutor Walter Mauricio Correa St., n/n, Botucatu, SP, ZIP- 18618-681, Brazil.
  • Pfeifer JPH; Department of Veterinary Surgery and Anesthesiology, São Paulo State University - Júlio de Mesquita Filho Unesp Prof. Doutor Walter Mauricio Correa St., n/n, Botucatu, SP, ZIP- 18618-681, Brazil.
  • Hussni CA; Department of Veterinary Surgery and Anesthesiology, São Paulo State University - Júlio de Mesquita Filho Unesp Prof. Doutor Walter Mauricio Correa St., n/n, Botucatu, SP, ZIP- 18618-681, Brazil.
  • Watanabe MJ; Department of Veterinary Surgery and Anesthesiology, São Paulo State University - Júlio de Mesquita Filho Unesp Prof. Doutor Walter Mauricio Correa St., n/n, Botucatu, SP, ZIP- 18618-681, Brazil.
  • Alves ALG; Department of Veterinary Surgery and Anesthesiology, São Paulo State University - Júlio de Mesquita Filho Unesp Prof. Doutor Walter Mauricio Correa St., n/n, Botucatu, SP, ZIP- 18618-681, Brazil.
J Mater Sci Mater Med ; 32(12): 144, 2021 Dec 04.
Article em En | MEDLINE | ID: mdl-34862929
Magnesium is a metal used in the composition of titanium alloys and imparts porosity. Due to its osteoconductive, biocompatible and biodegradable characteristics, its application in the development of biomedical materials has become attractive. This study aimed to evaluate the influence of magnesium present in porous Ti-Nb-Sn alloys, which have a low elastic modulus in adhesive, osteogenic properties and the amount of reactive intracellular oxygen species released in mesenchymal stem cells derived from bone marrow equine bone (eBMMSCs). Mechanical properties of the alloy, such as hardness, compressive strength and elastic modulus, were analyzed, as well as surface morphological characteristics through scanning electron microscopy. The evaluation of magnesium ion release was performed by atomic force spectroscopy. The biological characteristics of the alloy, when in contact with the alloy surface and with the culture medium conditioned with the alloy, were studied by SEM and optical microscopy. Confirmation of osteogenic differentiation by alizarin red and detection of ROS using a Muse® Oxidative Stress Kit based on dihydroetide (DHE). The alloy showed an elastic modulus close to cortical bone values. The hardness was close to commercial Ti grade 2, and the compressive strength was greater than the value of cortical bone. The eBMMSCs adhered to the surface of the alloy during the experimental time. Osteogenic differentiation was observed with the treatment of eBMMMSCs with conditioned medium. The eBMMSCs treated with conditioned medium decreased ROS production, indicating a possible antioxidant defense potential of magnesium release.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Estanho / Titânio / Células da Medula Óssea / Ligas / Nióbio Limite: Animals Idioma: En Revista: J Mater Sci Mater Med Assunto da revista: ENGENHARIA BIOMEDICA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Estanho / Titânio / Células da Medula Óssea / Ligas / Nióbio Limite: Animals Idioma: En Revista: J Mater Sci Mater Med Assunto da revista: ENGENHARIA BIOMEDICA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos