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Intranasal oxygen reverses hypoxaemia in immobilised free-ranging capybaras (Hydrochoerus hydrochaeris).
Cordeiro, Jefferson F; Sanches, Mariana C; Rusch, Elidiane; Xavier, Nathalia V; Cassoli, Ana Angélica; Fahlman, Åsa; Carregaro, Adriano B.
Afiliação
  • Cordeiro JF; Veterinary Medicine Department, Faculty of Animal Science and Food Engineering, University of São Paulo (USP), Pirassununga, SP, Brazil.
  • Sanches MC; Veterinary Medicine Department, Faculty of Animal Science and Food Engineering, University of São Paulo (USP), Pirassununga, SP, Brazil.
  • Rusch E; Veterinary Medicine Department, Faculty of Animal Science and Food Engineering, University of São Paulo (USP), Pirassununga, SP, Brazil.
  • Xavier NV; Veterinary Medicine Department, Faculty of Animal Science and Food Engineering, University of São Paulo (USP), Pirassununga, SP, Brazil.
  • Cassoli AA; Veterinary Medicine Department, Faculty of Animal Science and Food Engineering, University of São Paulo (USP), Pirassununga, SP, Brazil.
  • Fahlman Å; Swedish Biodiversity Centre, Department of Urban and Rural Development, Swedish University of Agricultural Sciences (SLU), Uppsala, Sweden.
  • Carregaro AB; Veterinary Medicine Department, Faculty of Animal Science and Food Engineering, University of São Paulo (USP), Pirassununga, SP, Brazil.
PLoS One ; 16(11): e0260441, 2021.
Article em En | MEDLINE | ID: mdl-34847151
Capybara (Hydrochoerus hydrochaeris) is the main host of tick-borne pathogens causing Brazilian spotted fever; therefore, controlling its population is essential, and this may require chemical restraint. We assessed the impact of chemical restraint protocols on the partial pressure of arterial oxygen (PaO2) and other blood variables in 36 capybaras and the effect of different flows of nasal oxygen (O2) supplementation. The capybaras were hand-injected with dexmedetomidine (5 µg/kg) and midazolam (0.1 mg/kg) and butorphanol (0.2 mg/kg) (DMB, n = 18) or methadone (0.1 mg/kg) (DMM, n = 18). One-third of the animals were maintained in ambient air throughout the procedure, and one-third were administered intranasal 2 L/min O2 after 30 min whereas the other third were administered 5 L/min O2. Arterial blood gases, acid-base status, and electrolytes were assessed 30 and 60 min after drug injection. The DMB and DMM groups did not vary based on any of the evaluated variables. All animals developed hypoxaemia (PaO2 44 [30; 73] mmHg, SaO2 81 [62; 93] %) 30 min before O2 supplementation. Intranasal O2 at 2 L/min improved PaO2 (63 [49; 97] mmHg and SaO2 [92 [85; 98] %), but 9 of 12 capybaras remained hypoxaemic. A higher O2 flow of 5 L/min was efficient in treating hypoxaemia (PaO2 188 [146; 414] mmHg, SaO2 100 [99; 100] %) in all the 12 animals that received it. Both drug protocols induced hypoxaemia, which could be treated with intranasal oxygen supplementation.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Oxigênio / Roedores / Hipóxia Limite: Animals Idioma: En Revista: PLoS One Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Oxigênio / Roedores / Hipóxia Limite: Animals Idioma: En Revista: PLoS One Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos