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Influence of galantamine in the inflammatory process and tissular lesions caused by Trypanosoma cruzi QM2 strain.
Camargo, Lucas Fadel; Pinheiro, Guilherme Donzalisky; Oliveira, Priscilla Bianca de; Losada, Daniele Moraes; Chagas, Eduardo Federighi Baisi; Sperança, Márcia Aparecida; Chies, Agnaldo Bruno; Spadella, Maria Angélica; Martins, Luciamáre Perinetti Alves.
Afiliação
  • Camargo LF; Faculdade de Medicina de Marília, Curso de Medicina, Marília, SP, Brasil.
  • Pinheiro GD; Faculdade de Medicina de Marília, Curso de Medicina, Marília, SP, Brasil.
  • Oliveira PB; Faculdade de Medicina de Marília, Departamento de Farmacologia, Marília, SP, Brasil.
  • Losada DM; Universidade Estadual de Campinas, Departamento de Anatomia Patológica, Campinas, SP, Brasil.
  • Chagas EFB; Faculdade de Medicina de Marília, Grupo de Estudo em Envelhecimento e Obesidade, Marília, SP, Brasil.
  • Sperança MA; Universidade Federal do ABC, Centro de Ciências Naturais e Humanas, São Bernardo do Campo, SP, Brasil.
  • Chies AB; Faculdade de Medicina de Marília, Departamento de Farmacologia, Marília, SP, Brasil.
  • Spadella MA; Faculdade de Medicina de Marília, Laboratório de Embriologia Humana, Marília, SP, Brasil.
  • Martins LPA; Faculdade de Medicina de Marília, Departamento de Parasitologia, Marília, SP, Brasil.
Rev Soc Bras Med Trop ; 54: e0201, 2021.
Article em En | MEDLINE | ID: mdl-34787259
INTRODUCTION: Trypanosoma cruzi infection triggers an inflammatory process with exacerbated production of cytokines that stimulate inflammatory and anti-inflammatory signals, including the efferent anti-inflammatory signal known as the anti-inflammatory cholinergic pathway. Thus, the use of anticholinesterase drugs, such as galantamine, could minimize the inflammatory process caused by this disease. METHODS: For the study at 30, 60, and 90 days, 120 Swiss mice were divided into three groups. Each group was subdivided into four subgroups: uninfected/untreated (CTRL), uninfected/treated (GAL), infected/untreated (INF), and infected/treated (GAL/INF). The infected groups were inoculated intraperitoneally with 0.1 ml of mouse blood containing 5 × 104 trypomastigote forms of the T. cruzi QM2 strain. The galantamine-treated groups received 5 mg/kg of galantamine orally, through pipetting. From each subgroup, the parameters of parasitemia, histopathological analysis, butyrylcholinesterase activity (BuChE), and functional study of the colon were evaluated. RESULTS: BuChE performance was observed when AChE was suppressed, with increased activity in the GAL/INF group similar to the INF group on the 30th day post infection, thus corroborating the absence of a significant difference in parasitic curves and histopathological analysis. CONCLUSIONS: The presence of an inflammatory process and nests of amastigotes, as well as evidence of reactivity to ACh and NOR, suggest that galantamine did not interfere with the colonic inflammatory response or even in colonic tissue parasitism at this stage of Chagas disease.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Trypanosoma cruzi / Doença de Chagas Limite: Animals Idioma: En Revista: Rev Soc Bras Med Trop Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Trypanosoma cruzi / Doença de Chagas Limite: Animals Idioma: En Revista: Rev Soc Bras Med Trop Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil