Your browser doesn't support javascript.
loading
Immunoprofiling of fresh HAM/TSP blood samples shows altered innate cell responsiveness.
Rocamonde, Brenda; Futsch, Nicolas; Orii, Noemia; Allatif, Omran; Penalva de Oliveira, Augusto Cesar; Mahieux, Renaud; Casseb, Jorge; Dutartre, Hélène.
Afiliação
  • Rocamonde B; International Center for Research in Infectiology, Retroviral Oncogenesis Laboratory, INSERM U1111-Université Claude Bernard Lyon 1, CNRS, Ecole Normale Supérieure de Lyon, Université Lyon, Lyon, France, Equipe labelisée par la Fondation pour la Recherche Médicale, Labex Ecofect.
  • Futsch N; International Center for Research in Infectiology, Retroviral Oncogenesis Laboratory, INSERM U1111-Université Claude Bernard Lyon 1, CNRS, Ecole Normale Supérieure de Lyon, Université Lyon, Lyon, France, Equipe labelisée par la Fondation pour la Recherche Médicale, Labex Ecofect.
  • Orii N; Faculdade de Medicina/Instituto de Medicina Tropical de São Paulo/Universidade da São Paulo, São Paulo, SP, Brazil.
  • Allatif O; International Center for Research in Infectiology, service BIBS, INSERM U1111-Université Claude Bernard Lyon 1, CNRS, Ecole Normale Supérieure de Lyon, Université Lyon, Lyon, France.
  • Penalva de Oliveira AC; Instituto de Infectologia "Emilio Ribas", São Paulo, SP, Brazil.
  • Mahieux R; International Center for Research in Infectiology, Retroviral Oncogenesis Laboratory, INSERM U1111-Université Claude Bernard Lyon 1, CNRS, Ecole Normale Supérieure de Lyon, Université Lyon, Lyon, France, Equipe labelisée par la Fondation pour la Recherche Médicale, Labex Ecofect.
  • Casseb J; Faculdade de Medicina/Instituto de Medicina Tropical de São Paulo/Universidade da São Paulo, São Paulo, SP, Brazil.
  • Dutartre H; International Center for Research in Infectiology, Retroviral Oncogenesis Laboratory, INSERM U1111-Université Claude Bernard Lyon 1, CNRS, Ecole Normale Supérieure de Lyon, Université Lyon, Lyon, France, Equipe labelisée par la Fondation pour la Recherche Médicale, Labex Ecofect.
PLoS Negl Trop Dis ; 15(11): e0009940, 2021 11.
Article em En | MEDLINE | ID: mdl-34767551
The Human T-cell Leukemia Virus-1 (HTLV-1)-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) is a devastating neurodegenerative disease with no effective treatment, which affects an increasing number of people in Brazil. Immune cells from the adaptive compartment are involved in disease manifestation but whether innate cell functions participate in disease occurrence has not been evaluated. In this study, we analyzed innate cell responses at steady state and after blood cell stimulation using an agonist of the toll-like receptor (TLR)7/8-signaling pathway in blood samples from HTLV-1-infected volunteers, including asymptomatic carriers and HAM/TSP patients. We observed a lower response of IFNα+ DCs and monocytes in HAM/TSP compared to asymptomatic carriers, as a potential consequence of corticosteroid treatments. In contrast, a higher frequency of monocytes producing MIP-1α and pDC producing IL-12 was detected in HAM/TSP blood samples, together with higher IFNγ responsiveness of NK cells, suggesting an increased sensitivity to inflammatory response in HAM/TSP patients compared to asymptomatic carriers. This sustained inflammatory responsiveness could be linked or be at the origin of the neuroinflammatory status in HAM/TSP patients. Therefore, the mechanism underlying this dysregulations could shed light onto the origins of HAM/TSP disease.
Assuntos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Paraparesia Espástica Tropical / Imunidade Inata Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male / Middle aged País/Região como assunto: America do sul / Brasil Idioma: En Revista: PLoS Negl Trop Dis Assunto da revista: MEDICINA TROPICAL Ano de publicação: 2021 Tipo de documento: Article País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Paraparesia Espástica Tropical / Imunidade Inata Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male / Middle aged País/Região como assunto: America do sul / Brasil Idioma: En Revista: PLoS Negl Trop Dis Assunto da revista: MEDICINA TROPICAL Ano de publicação: 2021 Tipo de documento: Article País de publicação: Estados Unidos