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Association between maternal infections during pregnancy and congenital defects in their offspring: a population-based case-control study in Bogota and Cali, Colombia 2001-2018.
Rumbo, Jose; Madariaga-P, Ithzayana; Salazar-Reviakina, Alexander; Sierra-Breton, Maria; Tovar, Catherin; Sequera, Diana; Rodríguez, Catherin; Holguín, Jorge; Hurtado-Villa, Paula; Sarmiento, Karen; Zarante, Ignacio.
Afiliação
  • Rumbo J; Faculty of Medicine, Pontificia Universidad Javeriana, Bogota, Colombia.
  • Madariaga-P I; Institute of Human Genetics, Pontificia Universidad Javeriana, Bogota, Colombia.
  • Salazar-Reviakina A; Faculty of Medicine, Pontificia Universidad Javeriana, Bogota, Colombia.
  • Sierra-Breton M; Faculty of Medicine, Pontificia Universidad Javeriana, Bogota, Colombia.
  • Tovar C; Institute of Human Genetics, Pontificia Universidad Javeriana, Bogota, Colombia.
  • Sequera D; Faculty of Medicine, Pontificia Universidad Javeriana, Bogota, Colombia.
  • Rodríguez C; Secretaría Distrital de Salud de Bogotá, Bogota, Colombia.
  • Holguín J; Department of Public Health and Epidemiology, Pontificia Universidad Javeriana, Cali, Colombia.
  • Hurtado-Villa P; Department of Basic Sciences, Faculty of Health, Pontificia Universidad Javeriana, Cali, Colombia.
  • Sarmiento K; Department of Physiological Sciences, Faculty of Medicine, Pontificia Universidad Javeriana, Bogota, Colombia.
  • Zarante I; Institute of Human Genetics, Pontificia Universidad Javeriana, Bogota, Colombia.
J Matern Fetal Neonatal Med ; 35(25): 8723-8727, 2022 Dec.
Article em En | MEDLINE | ID: mdl-34749588
Infections are frequent during pregnancy and their teratogenic role is well documented in Toxoplasmosis, other infections, Rubella, Cytomegalovirus, and Herpes simplex (TORCH). However, the in-utero development effects of the rest of the infections that affect pregnant women are unknown. We described a cohort of patients with major Birth Defects (BD) and the exposure to infections during pregnancy from the information of Congenital Defects Surveillance Programs of two Colombian cities (Bogota and Cali) between 2001 and 2018. We evaluated associations between groups of maternal infections and BD among 3096 cases and 7446 controls that were registered. BD presentation was more frequent as isolated (64.3%), polymalformed (23.2%), and syndromic (12.4%). Infections during pregnancy were present in 52.5% of cases and 44.6% of controls. The most common single infection between cases and controls was vaginal infection. The most common polyinfection was vaginal and urinary tract infection. We found an association between BD and vaginal infections with an odds ratio (OR) 1.18 (CI 1.08-1.30), urinary tract infections OR 1.16 (CI 1.05-1.28), gastrointestinal infections OR 2.06 (IC 1.18-3.59), respiratory infections OR 1.56 (IC 1.28-1.9) and viral infections OR 1.88 (IC 1.18-3.0). Knowing the teratogenic effect of infections is important to extend prevention, screening, timely diagnosis, and appropriate treatment to pregnant women.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Complicações Infecciosas na Gravidez / Rubéola (Sarampo Alemão) / Toxoplasmose Tipo de estudo: Diagnostic_studies / Observational_studies / Risk_factors_studies Limite: Female / Humans / Pregnancy País/Região como assunto: America do sul / Colombia Idioma: En Revista: J Matern Fetal Neonatal Med Assunto da revista: OBSTETRICIA / PERINATOLOGIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Colômbia País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Complicações Infecciosas na Gravidez / Rubéola (Sarampo Alemão) / Toxoplasmose Tipo de estudo: Diagnostic_studies / Observational_studies / Risk_factors_studies Limite: Female / Humans / Pregnancy País/Região como assunto: America do sul / Colombia Idioma: En Revista: J Matern Fetal Neonatal Med Assunto da revista: OBSTETRICIA / PERINATOLOGIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Colômbia País de publicação: Reino Unido