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PanB over-representation as part of pyrazinamide action: a proteomic insight.
Barros, Isabella Letícia Esteves; Meneguello, Jean Eduardo; Ghiraldi-Lopes, Luciana Dias; Arita, Gláucia Sayuri; de Oliveira Silva, João Vitor; Ferracioli, Katiany Rizzieri Caleffi; de Lima Scodro, Regiane Bertin; Siqueira, Vera Lucia Dias; Pilau, Eduardo Jorge; Campanerut-Sá, Paula Aline Zanetti; Cardoso, Rosilene Fressatti.
Afiliação
  • Barros ILE; Postgraduate Program in Health Sciences, State University of Maringá, 87020-900, PR, Brazil.
  • Meneguello JE; Postgraduate Program in Biosciences & Physiopathology, State University of Maringá, 87020-900, PR, Brazil.
  • Ghiraldi-Lopes LD; Department of Clinical Analysis & Biomedicine, State University of Maringá, 87020-900, PR, Brazil.
  • Arita GS; Postgraduate Program in Biosciences & Physiopathology, State University of Maringá, 87020-900, PR, Brazil.
  • de Oliveira Silva JV; Postgraduate Program in Health Sciences, State University of Maringá, 87020-900, PR, Brazil.
  • Ferracioli KRC; Postgraduate Program in Biosciences & Physiopathology, State University of Maringá, 87020-900, PR, Brazil.
  • de Lima Scodro RB; Department of Clinical Analysis & Biomedicine, State University of Maringá, 87020-900, PR, Brazil.
  • Siqueira VLD; Postgraduate Program in Health Sciences, State University of Maringá, 87020-900, PR, Brazil.
  • Pilau EJ; Department of Clinical Analysis & Biomedicine, State University of Maringá, 87020-900, PR, Brazil.
  • Campanerut-Sá PAZ; Postgraduate Program in Biosciences & Physiopathology, State University of Maringá, 87020-900, PR, Brazil.
  • Cardoso RF; Department of Clinical Analysis & Biomedicine, State University of Maringá, 87020-900, PR, Brazil.
Future Microbiol ; 16: 1303-1308, 2021 11.
Article em En | MEDLINE | ID: mdl-34743541
Background: Pyrazinamide (PZA) represents a milestone as a first-line antituberculosis drug due to its sterilizing activity against Mycobacterium tuberculosis. Materials & Methods: The protein changes induced by subinhibitory PZA exposure of M. tuberculosis in acidic pH were evaluated by a proteomic approach. Results: Among the 1059 M. tuberculosis proteins identified, the specific acidification in the culture medium induced the over-representation of MurF (Rv2157c), and its under-representation was induced by 12 h of PZA exposure. PanB (Rv2225) was over-represented at 24 h of PZA exposure. Conclusion: The authors highlight the over-representation of PanB in M. tuberculosis correlates of PZA action in acidic pH, reinforcing the role of the pantothenate pathway as a bacillus drug target to be explored.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tuberculose / Mycobacterium tuberculosis Limite: Humans Idioma: En Revista: Future Microbiol Assunto da revista: MICROBIOLOGIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tuberculose / Mycobacterium tuberculosis Limite: Humans Idioma: En Revista: Future Microbiol Assunto da revista: MICROBIOLOGIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido