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Gestational stress alters maternal behavior and inflammatory markers in the olfactory bulb of lactating mice.
Luft, Carolina; Wearick-Silva, Luis Eduardo; da Costa, Mariana Severo; Pedrazza, Leonardo; Antunes, Géssica Luana; Grassi-Oliveira, Rodrigo; de Oliveira, Jarbas Rodrigues; Donadio, Márcio Vinícius Fagundes.
Afiliação
  • Luft C; Laboratory of Pediatric Physical Activity, Infant Center, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Porto Alegre, Brazil.
  • Wearick-Silva LE; Laboratory of Cellular Biophysics and Inflammation, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Porto Alegre, Brazil.
  • da Costa MS; Developmental Cognitive Neuroscience Laboratory (DCNL), Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Porto Alegre, Brazil.
  • Pedrazza L; Laboratory of Pediatric Physical Activity, Infant Center, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Porto Alegre, Brazil.
  • Antunes GL; Laboratory of Ubiquitination and Celular Signalization, IDIBELL, Campus de Bellvitge, Universitat de Barcelona, L'Hospitalet de Llobregat, Barcelona, Spain.
  • Grassi-Oliveira R; Laboratory of Cellular Biophysics and Inflammation, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Porto Alegre, Brazil.
  • de Oliveira JR; Developmental Cognitive Neuroscience Laboratory (DCNL), Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Porto Alegre, Brazil.
  • Donadio MVF; Laboratory of Cellular Biophysics and Inflammation, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Porto Alegre, Brazil.
Int J Dev Neurosci ; 82(2): 180-187, 2022 Apr.
Article em En | MEDLINE | ID: mdl-34734422
Inflammatory markers represent important candidates responsible for the altered behavior and physiology observed after stressful experiences. In the maternal brain, the olfactory bulb (OB) is a key constituent of the neural circuit that mediates the reciprocal interaction between mother and infant. This study aimed to investigate the effects of stress during pregnancy on maternal behavior and inflammatory changes in the olfactory bulb of lactating mice. Female Balb/c mice were divided into two groups: control (CT) and restraint stress (RS). Maternal behavior was performed during the first 8 days of life of the offspring. On the 10th day after parturition, corticosterone, gene, and protein expression were assessed. Stress during pregnancy decreased the maternal index at postnatal day 4 and the nuclear factor-κB 1 (NFκB1) gene expression in the OB. Moreover, females from the RS group showed increased interleukin (IL-1ß) protein expression. In contrast, stressed females exhibited a decreased tumor necrosis factor (TNF-α) protein expression in the OB. In conclusion, exposure to stress during pregnancy was able to induce specific postnatal effects on maternal behavior and balance of inflammatory mediators in the OB.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Bulbo Olfatório / Efeitos Tardios da Exposição Pré-Natal Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans / Pregnancy Idioma: En Revista: Int J Dev Neurosci Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Bulbo Olfatório / Efeitos Tardios da Exposição Pré-Natal Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans / Pregnancy Idioma: En Revista: Int J Dev Neurosci Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos