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Punica granatum and amygdalin extracts plus cobalamin combined with albendazole reduce larval burden and myositis in experimental trichinosis.
Esmat, Marwa; Abdel-Aal, Amany Ahmed; Shalaby, Maisa Ahmed; Fahmy, Mennat-Elrahman Ahmed; Badawi, Manal Abdel Magid; Elmallawany, Marwa Adel; Magdy, Mona; Afife, Adam Ashraf; Shafi, Iman Raafat Abdel.
Afiliação
  • Esmat M; Department of Medical Parasitology, Faculty of Medicine, Misr University for Science and Technology, 6 October city, Egypt.
  • Abdel-Aal AA; Department of Medical Parasitology, Faculty of Medicine, Cairo University, Cairo, Egypt.
  • Shalaby MA; Department of Postgraduate Studies & Scientific Research, Armed Forces College of Medicine - AFCM, Cairo, Egypt.
  • Fahmy MA; Medical Parasitology Department, Theodor Bilharz Research Institute - TBRI, Giza, Egypt.
  • Badawi MAM; Medical Parasitology Department, Theodor Bilharz Research Institute - TBRI, Giza, Egypt.
  • Elmallawany MA; Department of Pathology, National Research Center, Giza, Egypt.
  • Magdy M; Department of Medical Parasitology, Faculty of Medicine, Cairo University, Cairo, Egypt.
  • Afife AA; Department of Pathology, Theodor Bilharz Research Institute - TBRI, Giza, Egypt.
  • Shafi IRA; College of Life Sciences, Faculty of Medicine, Leicester University, Leicester, United Kingdom.
Rev Bras Parasitol Vet ; 30(4): e012021, 2021.
Article em En | MEDLINE | ID: mdl-34730610
Trichinellosis is a zoonosis results from eating raw or semi-cooked meat of infected animals. Medicinal plants have been used lately as alternatives and/or combined therapies to resolve some drawbacks of the current regimens. This work analyzed the effect of albendazole monotherapy on Trichinella spiralis experimental infection (group A), in comparison to P. granatum and amygdalin extracts +cobalamin (group B), plus its combination with albendazole (group C). The study revealed that the extracts alone or combined with albendazole had an inferior effect to albendazole monotherapy regarding number of adult worms (40.83 ±3.82, 18.67 ±1.86 and 16.83 ±2.32, respectively). However, their effect was more obvious in muscle phase combined with albendazole, achieving the lower number of larvae/mL tissue homogenate (22.33 ±3.27 in comparison to 39.67 ±2.58 achieved by albendazole monotherapy). The extracts exerted a significant immunomodulatory effect by reducing the local CD4+ expression in the intestine as well as in muscle phase (1.15 ±0.25 and 3.80 ±0.65 in comparison to 4.97 ±0.37 and 12.20 ±0.87 with albendazole monotherapy, respectively). So, these extracts improved the therapeutic efficacy of albendazole, specifically in muscle phase and counteracted the inflammatory reaction caused by albendazole monotherapy, thus extensively alleviating the resulting myositis.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Triquinelose / Trichinella spiralis / Punica granatum / Amigdalina / Miosite Limite: Animals Idioma: En Revista: Rev Bras Parasitol Vet Assunto da revista: MEDICINA VETERINARIA / PARASITOLOGIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Egito País de publicação: Brasil
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Triquinelose / Trichinella spiralis / Punica granatum / Amigdalina / Miosite Limite: Animals Idioma: En Revista: Rev Bras Parasitol Vet Assunto da revista: MEDICINA VETERINARIA / PARASITOLOGIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Egito País de publicação: Brasil