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Polymorphism PLIN1 11482 G>A interacts with dietary intake to modulate anthropometric measures and lipid profile in adults with normal-weight obesity syndrome.
Holzbach, Luciana Carla; Silveira, Amanda Gonçalves Zardini; Franco, Lana Pacheco; Horst, Maria Aderuza; Cominetti, Cristiane.
Afiliação
  • Holzbach LC; Nutrition Undergraduate Course, Federal University of Tocantins, Quadra 109 Norte, Av. NS-15, Alcno-14, Bloco Bala I, Plano Diretor Norte, Palmas, TO, 77001-090, Brazil.
  • Silveira AGZ; Nutritional Genomics Research Group, School of Nutrition, Federal University of Goiás, Rua 227, Quadra 68, s/n. Setor Leste Universitário, Goiânia, GO, 74.605-080, Brazil.
  • Franco LP; Nutritional Genomics Research Group, School of Nutrition, Federal University of Goiás, Rua 227, Quadra 68, s/n. Setor Leste Universitário, Goiânia, GO, 74.605-080, Brazil.
  • Horst MA; Nutritional Genomics Research Group, School of Nutrition, Federal University of Goiás, Rua 227, Quadra 68, s/n. Setor Leste Universitário, Goiânia, GO, 74.605-080, Brazil.
  • Cominetti C; Nutritional Genomics Research Group, School of Nutrition, Federal University of Goiás, Rua 227, Quadra 68, s/n. Setor Leste Universitário, Goiânia, GO, 74.605-080, Brazil.
Br J Nutr ; 128(6): 1004-1012, 2022 09 28.
Article em En | MEDLINE | ID: mdl-34725012
Evidence shows that genetic polymorphisms in perilipin 1 gene (PLIN1) are associated with excessive accumulation of body fat and disturbances in cardiometabolic markers. Therefore, the aim of this study was to verify whether the SNP PLIN1 11482 G>A (rs894160) interacts with nutrient intake, anthropometric, body composition and cardiometabolic markers in adults with normal-weight obesity (NWO) syndrome. A cross-sectional study was carried out with 116 individuals aged 20-59 years, with normal BMI and high percentage of body fat. Anthropometric and body composition measures, glycaemic control and serum lipid markers, SNP PLIN1 11482 G>A and nutrient intake were evaluated. Interactions between nutrient intake and the SNP were determined by regression models and adjusted for potential confounders. The SNP frequency was 56·0 % GG, 38·8 % GA and 5·2 % AA. Anthropometric measures and biochemical markers were not different according to genotype, except for total cholesterol (TC), LDL-cholesterol and non-HDL-cholesterol concentrations. However, important interactions between the SNP and dietary intake were observed. Carbohydrate intake interacted with the SNP PLIN1 11482 G>A to modulate waist circumference (WC) and the homeostatic model assessment of insulin resistance index. Interaction of lipid intake and the SNP modulated TC and LDL-cholesterol concentrations, and the interaction between protein intake and the SNP tended to modulate weight, WC and BMI. The SNP PLIN1 11482 G>A seems to modulate responses in anthropometric and lipid profile biomarkers of subjects with NWO depending on the dietary macronutrient composition, which may have long-term impact on cardiometabolic markers.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças Cardiovasculares / Polimorfismo de Nucleotídeo Único Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Adult / Humans Idioma: En Revista: Br J Nutr Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
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XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças Cardiovasculares / Polimorfismo de Nucleotídeo Único Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Adult / Humans Idioma: En Revista: Br J Nutr Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido