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Stearic acid does not overcome conjugated linoleic acid trans-10, cis-12-induced milk fat depression in lactating ewes.
De Aguiar, Georgia C; Horstmann, Rafaella; Padilha, Charline Godinho; Ribeiro, Cláudio V D M; De Oliveira, Dimas Estrasulas.
Afiliação
  • De Aguiar GC; Department of Animal Production, Santa Catarina State University, Lages, Santa Catarina88520-000, Brazil.
  • Horstmann R; Department of Animal Production, Santa Catarina State University, Lages, Santa Catarina88520-000, Brazil.
  • Padilha CG; Department of Animal Production, Santa Catarina State University, Lages, Santa Catarina88520-000, Brazil.
  • Ribeiro CVDM; Department of Animal Science, Federal University of Bahia, Salvador, Bahia40170-110, Brazil.
  • De Oliveira DE; Department of Animal Production, Santa Catarina State University, Lages, Santa Catarina88520-000, Brazil.
Br J Nutr ; : 1-7, 2021 Oct 27.
Article em En | MEDLINE | ID: mdl-34704550
The objective of this study was to test the hypothesis that stearic acid (SA) supplementation increases milk fat content and overcomes the antilipogenic effects of trans-10, cis-12 conjugated linoleic acid (CLA) in lactating ewes. Twenty-eight Lacaune ewes (36 (sd 2) days in lactation; 70·5 (sd) 9·6 kg of body weight), producing 1·8 (sd 0·4) kg of milk/d, were used in a completely randomised design (seven ewes/treatment) for 21 d. The treatments were: (1) Control; (2) CLA (6·4 g/d of trans-10, cis-12 CLA); (3) SA (28 g/d of SA) and (4) SA in association with trans-10, cis-12 CLA (CLASA; 6·4 g/d of trans-10, cis-12 CLA plus 28 g/d of SA). All data were analysed using a mixed model that included the fixed effect of treatment and the random effect of ewe. SA did not alter milk fat content and yield relative to Control (91·9 v. 91·2 (sd 4·1) g/d). CLASA was not able to overcome the reduction in fat content and fat yield induced by CLA (75 v. 82 (sd 0·14) g/d). SA increased the relative abundance of CD36, fatty acid-binding protein 4 (FABP4) and PPAR-γ mRNA by 140, 112 and 68 % compared with CLASA. SA also reduced the relative abundance of acetyl-CoA carboxylase α promoter II and stearoyl-CoA desaturase (SCD) when compared with Control (45 and 39 %). Compared with CLA, CLASA treatment had no effect on the mRNA abundance of fatty acid synthase, lipoprotein lipase, CD36, SCD, FABP4, acylglycerolphosphate acyltransferase 6, sterol regulatory element-binding protein 1 and PPAR-γ. In conclusion, SA supplementation did not increase milk fat synthesis and did not overcome the CLA-induced milk fat depression when associated with trans-10, cis-12 CLA.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Clinical_trials Idioma: En Revista: Br J Nutr Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Clinical_trials Idioma: En Revista: Br J Nutr Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido