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Accelerative action of topical piperonylic acid on mice full thickness wound by modulating inflammation and collagen deposition.
Moreira, Karina Gomes; do Prado, Thais Paulino; Mendes, Natália Ferreira; de Medeiros Bezerra, Renan; Jara, Carlos Poblete; Melo Lima, Maria Helena; de Araujo, Eliana Pereira.
Afiliação
  • Moreira KG; School of Nursing, University of Campinas, Sao Paulo, Brazil.
  • do Prado TP; Laboratory of Cell Signaling, Yokohama, Japan.
  • Mendes NF; Obesity and Comorbidities Research Center, University of Campinas, Sao Paulo, Brazil.
  • de Medeiros Bezerra R; School of Nursing, University of Campinas, Sao Paulo, Brazil.
  • Jara CP; Laboratory of Cell Signaling, Yokohama, Japan.
  • Melo Lima MH; Obesity and Comorbidities Research Center, University of Campinas, Sao Paulo, Brazil.
  • de Araujo EP; School of Nursing, University of Campinas, Sao Paulo, Brazil.
PLoS One ; 16(10): e0259134, 2021.
Article em En | MEDLINE | ID: mdl-34699564
Epidermal growth factor (EGF) promotes cell growth, proliferation, and survival in numerous tissues. Piperonylic acid, a metabolite present in peppers (Piper nigrum L. and Piper longum L.), can bind to the epidermal growth factor receptor (EGFR) and induce an intracellular signaling cascade leading to the transcription of genes responsible for these actions, especially in keratinocytes. These cells are fundamental in maintaining cutaneous homeostasis and are the first to be damaged in the case of a wound. Thus, we hypothesized that piperonylic acid improves wound healing. C57BL6/J male mice were submitted to dorsal skin wounds caused by a 6 mm punch and treated topically with piperonylic acid or vehicle. The wounds were evaluated macro- and microscopically, and tissue samples were collected for immunofluorescence and real-time PCR analyses on days 6, 9 and 19 post-injury. Topical piperonylic acid improved wound healing from day 6 post-injury until closure. This phenomenon apparently occurred through EGFR activation. In addition, piperonylic acid modulated the gene expression of interleukin (Il)-6, il-1ß, tumor necrosis factor (Tnf)-α, il-10, monocyte chemoattractant protein (Mcp)-1 and insulin-like growth factor (Igf)-1, which are important for the healing process. By day 19 post-injury, the new tissue showed greater deposition of type I collagen and a morphology closer to intact skin, with more dermal papillae and hair follicles. We conclude that piperonylic acid may be a viable option for the treatment of skin wounds.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pele / Cicatrização / Benzoatos / Colágeno / Inflamação Limite: Animals Idioma: En Revista: PLoS One Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pele / Cicatrização / Benzoatos / Colágeno / Inflamação Limite: Animals Idioma: En Revista: PLoS One Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos