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The Mortality from Hereditary Angioedema Worldwide: a Review of the Real-World Data Literature.
Minafra, Fernanda Gontijo; Gonçalves, Tifany Rafaely; Alves, Thaís Martins; Pinto, Jorge Andrade.
Afiliação
  • Minafra FG; Department of Pediatrics, Universidade Federal de Minas Gerais, Belo Horizonte, Av. Professor Alfredo Balena, 190/267, Minas Gerais, Brazil. fminafra@gmail.com.
  • Gonçalves TR; Medical School, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
  • Alves TM; Medical School, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
  • Pinto JA; Department of Pediatrics, Universidade Federal de Minas Gerais, Belo Horizonte, Av. Professor Alfredo Balena, 190/267, Minas Gerais, Brazil.
Clin Rev Allergy Immunol ; 62(1): 232-239, 2022 Feb.
Article em En | MEDLINE | ID: mdl-34687444
This study aims to review the global mortality secondary to laryngeal edema in patients diagnosed with hereditary angioedema and their relatives over the years, as well as to describe epidemiological and clinical findings associated with this outcome. An extensive search of the literature was made in PubMed, Scopus, and Embase to identify mortality rates secondary to laryngeal edema in patients with hereditary angioedema. The search was carried out in September of 2020 and in April of 2021, and keywords based on the MeSH terms were searched in three databases. The filter of language was used for finding only articles in English, and there was no limit to the year of publication. A total of twenty-three articles fulfilled the inclusion criteria for review and data extraction. The analyzed studies included 3292 patients and 411 deaths from asphyxia due to laryngeal edema. One hundred and three deaths in close relatives were described as secondary to the same cause. The main findings were summarized in tables: year and place of publication, the number of patients and deaths from laryngeal edema, patients previously diagnosed, and death age. Death rates from laryngeal edema had an average of one death for every 20 patients. Eight studies reported deaths in relatives. For every 7.4 patients in these studies, one relative died. The percentage among deaths in general associated with laryngeal edema was evaluated in three studies (32.7%, 44.4%, and 56%). The high frequency of this outcome suggests that deaths still occur, and improvement of hereditary angioedema treatment still needs to be met.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Edema Laríngeo / Angioedemas Hereditários Tipo de estudo: Etiology_studies / Prognostic_studies / Systematic_reviews Limite: Humans Idioma: En Revista: Clin Rev Allergy Immunol Assunto da revista: ALERGIA E IMUNOLOGIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Edema Laríngeo / Angioedemas Hereditários Tipo de estudo: Etiology_studies / Prognostic_studies / Systematic_reviews Limite: Humans Idioma: En Revista: Clin Rev Allergy Immunol Assunto da revista: ALERGIA E IMUNOLOGIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos