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Adherence to a Fish-Rich Dietary Pattern Is Associated with Chronic Hepatitis C Patients Showing Low Viral Load: Implications for Nutritional Management.
Ojeda-Granados, Claudia; Panduro, Arturo; Gonzalez-Aldaco, Karina; Rivera-Iñiguez, Ingrid; Campos-Medina, Liliana; Roman, Sonia.
Afiliação
  • Ojeda-Granados C; Department of Molecular Biology in Medicine, Civil Hospital of Guadalajara "Fray Antonio Alcalde", Hospital #278, Col. El Retiro, Guadalajara 44280, Jalisco, Mexico.
  • Panduro A; Health Sciences Center, University of Guadalajara, Guadalajara 44340, Jalisco, Mexico.
  • Gonzalez-Aldaco K; Department of Molecular Biology in Medicine, Civil Hospital of Guadalajara "Fray Antonio Alcalde", Hospital #278, Col. El Retiro, Guadalajara 44280, Jalisco, Mexico.
  • Rivera-Iñiguez I; Health Sciences Center, University of Guadalajara, Guadalajara 44340, Jalisco, Mexico.
  • Campos-Medina L; Department of Molecular Biology in Medicine, Civil Hospital of Guadalajara "Fray Antonio Alcalde", Hospital #278, Col. El Retiro, Guadalajara 44280, Jalisco, Mexico.
  • Roman S; Health Sciences Center, University of Guadalajara, Guadalajara 44340, Jalisco, Mexico.
Nutrients ; 13(10)2021 Sep 23.
Article em En | MEDLINE | ID: mdl-34684338
Hepatitis C virus (HCV) infection is influenced by genetic (e.g., APOE polymorphisms) and environmental factors between the virus and the host. HCV modulates the host's lipid metabolism but dietary components influence lipids and in vitro HCV RNA replication. Few data exist on the role of dietary features or patterns (DPs) in HCV infection. Herein, we aimed to evaluate the nutritional profiles of chronic HCV (CHC) and spontaneous clearance (SC) Mexican patients in the context of APOE alleles and their correlation with HCV-related variables. The fibrosis-related APOEε3 allele prevailed in CHC and SC patients, who had four DPs ("meat and soft drinks", DP1; "processed animal and fried foods", DP2; "Mexican-healthy", DP3; and "fish-rich", DP4). In CHC subjects, polyunsaturated fatty acid intake (PUFA ≥ 4.9%) was negatively associated, and fiber intake (≥21.5 g/day) was positively associated with a high viral load (p < 0.036). High adherence to fish-rich DP4 was associated with a higher frequency of CHC individuals consuming PUFA ≥ 4.9% (p = 0.004) and low viral load (p = 0.036), but a lower frequency of CHC individuals consuming fiber ≥21.5 g/day (p = 0.038). In SC and CHC individuals, modifying unhealthy DPs and targeting HCV-interacting nutrients, respectively, could be part of a nutritional management strategy to prevent further liver damage.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cooperação do Paciente / Carga Viral / Hepatite C Crônica / Dieta / Peixes / Fenômenos Fisiológicos da Nutrição Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals / Female / Humans / Male / Middle aged Idioma: En Revista: Nutrients Ano de publicação: 2021 Tipo de documento: Article País de afiliação: México País de publicação: Suíça
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cooperação do Paciente / Carga Viral / Hepatite C Crônica / Dieta / Peixes / Fenômenos Fisiológicos da Nutrição Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals / Female / Humans / Male / Middle aged Idioma: En Revista: Nutrients Ano de publicação: 2021 Tipo de documento: Article País de afiliação: México País de publicação: Suíça