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Maternal high fructose diet exacerbates white adipose tissue thermogenic process in offspring upon exposure to cold temperature.
Alzamendi, A; Miguel, I; Zubiría, M G; Gambaro, S E; Spinedi, E; Giovambattista, A.
Afiliação
  • Alzamendi A; Laboratorio de Neuroendocrinología, Instituto Multidisciplinario de Biología Celular (IMBICE, CICPBA-CONICET-UNLP), Calle 526, 10 y 11, La Plata 1900, Argentina.
  • Miguel I; Laboratorio de Neuroendocrinología, Instituto Multidisciplinario de Biología Celular (IMBICE, CICPBA-CONICET-UNLP), Calle 526, 10 y 11, La Plata 1900, Argentina.
  • Zubiría MG; Laboratorio de Neuroendocrinología, Instituto Multidisciplinario de Biología Celular (IMBICE, CICPBA-CONICET-UNLP), Calle 526, 10 y 11, La Plata 1900, Argentina.
  • Gambaro SE; Laboratorio de Neuroendocrinología, Instituto Multidisciplinario de Biología Celular (IMBICE, CICPBA-CONICET-UNLP), Calle 526, 10 y 11, La Plata 1900, Argentina.
  • Spinedi E; Centro de Endocrinología Experimental y Aplicada (CENEXA, UNLP-CONICET), Facultad de Cs. Médicas, Universidad Nacional de La Plata, Avenida 60 y 120, La Plata 1900, Argentina.
  • Giovambattista A; Laboratorio de Neuroendocrinología, Instituto Multidisciplinario de Biología Celular (IMBICE, CICPBA-CONICET-UNLP), Calle 526, 10 y 11, La Plata 1900, Argentina. Electronic address: agiovamba@gmail.com.
Life Sci ; 287: 120066, 2021 Dec 15.
Article em En | MEDLINE | ID: mdl-34678264
AIM: An adverse endogenous environment during early life predisposes to metabolic disorder development. We previously reported adverse metabolic and adipose tissue effects in adult male rats born to dams fed with a fructose-rich diet (FRD). The aim of this work was to determine the effect of a FRD consumed by the pregnant mother on the white adipose tissue (WAT) browning capacity of male offspring at adulthood. MAIN METHODS: Adult SD male offspring from control (C) and FRD-fed mothers were exposed during one week to a cold stimulus. WAT browning capacity was studied through in vivo and in vitro approaches. KEY FINDINGS: After cold exposure, WAT browning was higher in fructose-programmed animals as evidenced by an increase in ucp-1 gene expression, protein levels, and higher UCP-1 positive foci. Moreover, pgc1-α gene expression was increased. In vitro studies showed a lower adipogenic capacity in cells of prenatally fructose-exposed animals differentiated with a white differentiation cocktail, while a higher ucp-1 expression was noted when their cells were treated with a pro-beige differentiation cocktail. SIGNIFICANCE: For the first time we demonstrate that pre-natal fructose exposure predisposes programmed male rats to a higher WAT browning-induced response, under stimulated conditions, despite an apparent lower basal thermogenic capacity. These results should be considered in future studies to generate new therapeutic approaches to deal with adverse programming malnutrition effects.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Efeitos Tardios da Exposição Pré-Natal / Temperatura Baixa / Termogênese / Tecido Adiposo Branco / Açúcares da Dieta / Frutose Limite: Animals / Pregnancy Idioma: En Revista: Life Sci Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Argentina País de publicação: Holanda
Texto completo
Adicionar na Minha BVS
Imprimir
XML
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Efeitos Tardios da Exposição Pré-Natal / Temperatura Baixa / Termogênese / Tecido Adiposo Branco / Açúcares da Dieta / Frutose Limite: Animals / Pregnancy Idioma: En Revista: Life Sci Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Argentina País de publicação: Holanda