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Serum Cystatin C as a predictor of acute kidney injury in neonates: a meta-analysis.
Yang, Hui; Lin, Chunlan; Zhuang, Chunyu; Chen, Jiacheng; Jia, Yanping; Shi, Huiling; Zhuang, Cong.
Afiliação
  • Yang H; Hainan Provincial Hospital of Traditional Chinese Medicine, Department of Gynecology and Obstetrics, Haikou, China.
  • Lin C; Haikou Maternal and Child Health Hospital, Department of Neonatal Pediatrics, Haikou, China.
  • Zhuang C; Haikou Maternal and Child Health Hospital, Nursing Department, Haikou, China.
  • Chen J; Hainan Provincial People's Hospital, Department of Hepatological Surgery, Haikou, China.
  • Jia Y; Haikou Maternal and Child Health Hospital, Department of Neonatal Pediatrics, Haikou, China.
  • Shi H; Haikou Maternal and Child Health Hospital, Department of Child Healthcare, Haikou, China.
  • Zhuang C; Haikou Hospital Affiliated to Xiangya Medical College of Central South University, Nursing Department, Haikou, China. Electronic address: hk987652021@163.com.
J Pediatr (Rio J) ; 98(3): 230-240, 2022.
Article em En | MEDLINE | ID: mdl-34662539
OBJECTIVES: The objective of this meta-analysis is to evaluate the diagnostic value of serum Cystatin C in acute kidney injury (AKI) in neonates. SOURCES: PubMed, Embase, Cochrane Library, Web of Science, China National Knowledge Infrastructure (CNKI), and WanFang Database were searched to retrieve the literature related to the diagnostic value of Cystatin C for neonatal AKI from inception to May 10, 2021. Subsequently, the quality of included studies was determined using the QUADAS-2 tool. Stata 15.0 statistical software was used to calculate the combined sensitivity (SEN), specificity (SPE), positive likelihood ratio (PLR), negative likelihood ratio (NLR), and diagnostic odds ratio (DOR). Additionally, meta-regression analysis and subgroup analysis contributed to explore the sources of heterogeneity. SUMMARY OF THE FINDINGS: Twelve articles were included. The pooled sensitivity was 0.84 (95%CI: 0.74-0.91), the pooled specificity was 0.81 (95%CI: 0.75-0.86), the pooled PLR was 4.39 (95%CI: 3.23-5.97), the pooled NLR was 0.19 (95%CI: 0.11-0.34), and the DOR was 22.58 (95%CI: 10.44-48.83). The area under the receiver operating characteristic curve (AUC) was 0.88 (95%CI: 0.85-0.90). No significant publication bias was identified (p > 0.05). CONCLUSIONS: Serum Cystatin C has a good performance in predicting neonatal AKI; therefore, it can be used as a candidate biomarker after the optimal level is determined by large prospective studies.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cistatina C / Injúria Renal Aguda Tipo de estudo: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Limite: Female / Humans / Male / Newborn Idioma: En Revista: J Pediatr (Rio J) Ano de publicação: 2022 Tipo de documento: Article País de afiliação: China País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cistatina C / Injúria Renal Aguda Tipo de estudo: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Limite: Female / Humans / Male / Newborn Idioma: En Revista: J Pediatr (Rio J) Ano de publicação: 2022 Tipo de documento: Article País de afiliação: China País de publicação: Brasil