Conditioned CAR-T cells by hypoxia-inducible transcription amplification (HiTA) system significantly enhances systemic safety and retains antitumor efficacy.

He, Huan; Liao, Qibin; Zhao, Chen; Zhu, Cuisong; Feng, Meiqi; Liu, Zhuoqun; Jiang, Lang; Zhang, Linxia; Ding, Xiangqing; Yuan, Min; Zhang, Xiaoyan; Xu, Jianqing

He, Huan; Liao, Qibin; Zhao, Chen; Zhu, Cuisong; Feng, Meiqi; Liu, Zhuoqun; Jiang, Lang; Zhang, Linxia; Ding, Xiangqing; Yuan, Min; Zhang, Xiaoyan; Xu, Jianqing.

Afiliação

He H; Shanghai Public Health Clinical Center & Institutes of Biomedical Sciences, Fudan University, Shanghai, China.
Liao Q; Shanghai Public Health Clinical Center & Institutes of Biomedical Sciences, Fudan University, Shanghai, China.
Zhao C; Shanghai Public Health Clinical Center & Institutes of Biomedical Sciences, Fudan University, Shanghai, China.
Zhu C; Shanghai Public Health Clinical Center & Institutes of Biomedical Sciences, Fudan University, Shanghai, China.
Feng M; Shanghai Public Health Clinical Center & Institutes of Biomedical Sciences, Fudan University, Shanghai, China.
Liu Z; Shanghai Public Health Clinical Center & Institutes of Biomedical Sciences, Fudan University, Shanghai, China.
Jiang L; Shanghai Public Health Clinical Center & Institutes of Biomedical Sciences, Fudan University, Shanghai, China.
Zhang L; Shanghai Public Health Clinical Center & Institutes of Biomedical Sciences, Fudan University, Shanghai, China.
Ding X; Shanghai Public Health Clinical Center & Institutes of Biomedical Sciences, Fudan University, Shanghai, China.
Yuan M; Shanghai Public Health Clinical Center, Shanghai, China xujianqing@shphc.org.cn zhangxiaoyan@shphc.org.cn yuanmin@shphc.org.cn.
Zhang X; Shanghai Public Health Clinical Center & Institutes of Biomedical Sciences, Fudan University, Shanghai, China xujianqing@shphc.org.cn zhangxiaoyan@shphc.org.cn yuanmin@shphc.org.cn.
Xu J; Shanghai Public Health Clinical Center & Institutes of Biomedical Sciences, Fudan University, Shanghai, China xujianqing@shphc.org.cn zhangxiaoyan@shphc.org.cn yuanmin@shphc.org.cn.

J Immunother Cancer ; 9(10)2021 10.

Article em En | MEDLINE | ID: mdl-34615704

Assuntos

Hipóxia Celular/genética; Amplificação de Genes/genética; Imunoterapia/métodos; Neoplasias/genética; Receptores de Antígenos Quiméricos/metabolismo; Animais; Linhagem Celular Tumoral; Modelos Animais de Doenças; Humanos; Camundongos

Palavras-chave

cell engineering; chimeric antigen; immunotherapy; receptors; tumor microenvironment

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hipóxia Celular / Amplificação de Genes / Receptores de Antígenos Quiméricos / Imunoterapia / Neoplasias Limite: Animals / Humans Idioma: En Revista: J Immunother Cancer Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China País de publicação: Reino Unido

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