Your browser doesn't support javascript.
loading
Salivary nitrite and systemic biomarkers in obese individuals with periodontitis submitted to FMD.
Cortelli, Sheila C; Máximo, Priscila de Macedo; Peralta, Felipe S; Silva, Rodrigo Augusto da; Rovai, Emanuel S; Costa, Fernando O; Aquino, Davi R; Rodrigues, Edson; Cortelli, Jose R.
Afiliação
  • Cortelli SC; Department of Dentistry, Periodontics Research Division, University of Taubaté, Taubaté, São Paulo, Brazil.
  • Máximo PM; Department of Dentistry, Periodontics Research Division, University of Taubaté, Taubaté, São Paulo, Brazil.
  • Peralta FS; Department of Dentistry, Periodontics Research Division, University of Taubaté, Taubaté, São Paulo, Brazil.
  • Silva RAD; Department of Dentistry, Periodontics Research Division, University of Taubaté, Taubaté, São Paulo, Brazil.
  • Rovai ES; Department of Dentistry, Periodontics Research Division, University of Taubaté, Taubaté, São Paulo, Brazil.
  • Costa FO; Department of Dentistry, Periodontics Research Division, University of Taubaté, Taubaté, São Paulo, Brazil.
  • Aquino DR; School of Dentistry, Department of Periodontology, Federal University of Minas Gerais, Brazil.
  • Rodrigues E; Institute of Bioscience, Biochemistry Division, University of Taubaté, Taubaté, São Paulo, Brazil.
  • Cortelli JR; Department of Dentistry, Periodontics Research Division, University of Taubaté, Taubaté, São Paulo, Brazil.
Braz Dent J ; 32(2): 27-36, 2021.
Article em En | MEDLINE | ID: mdl-34614058
The objective of this 9-month clinical study is to assess the impact of one-stage full-mouth disinfection (FMD) on salivary nitrite levels and systemic biomarkers and its correlation with total subgingival bacterial load in obese and non-obese patients with periodontitis. In total, 94 patients (55 obese and 39 non-obese) were initially evaluated, seven were lost during follow-up, resulting in 87 individuals at the end of the study. Outcomes were assessed at baseline, 3, 6, and 9 months post periodontal treatment by FMD. Salivary nitrite levels were determined using Griess reagent. Blood samples were collected to determine C-Reactive Protein (CRP), alkaline phosphatase and fasting blood glucose. Real-time PCR was used to determine the total subgingival bacterial load. FMD protocol resulted in increased salivary nitrite levels at 6- and 9-months post-treatment in the non-obese group (p<0.05). In obese individuals, FMD treatment led to an increase in salivary nitrite levels at 6 months (p<0.05); however, at 9 months, the nitrite levels returned to baseline levels. For both groups, the highest nitrite values were observed at 6 months. In addition, in both groups, FMD was associated with a decrease in biomarkers related to systemic inflammation and cardiovascular diseases, such as CRP (p<0.05) and alkaline phosphatase (p<0.05), and had no impact on the fasting blood glucose. This study demonstrates that obese patients with periodontitis present similar salivary nitrite levels when compared with non-obese individuals. FMD protocol resulted in increases in salivary nitrite levels and was associated with a positive impact on systemic biomarkers, regardless of obesity status.
Assuntos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Periodontite / Nitritos Tipo de estudo: Guideline Limite: Humans Idioma: En Revista: Braz Dent J Assunto da revista: ODONTOLOGIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Periodontite / Nitritos Tipo de estudo: Guideline Limite: Humans Idioma: En Revista: Braz Dent J Assunto da revista: ODONTOLOGIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil