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Phenolic compounds that cross the blood-brain barrier exert positive health effects as central nervous system antioxidants.
Velásquez-Jiménez, Dafne; Corella-Salazar, Diana A; Zuñiga-Martínez, B Shain; Domínguez-Avila, J Abraham; Montiel-Herrera, Marcelino; Salazar-López, Norma J; Rodrigo-Garcia, Joaquín; Villegas-Ochoa, Mónica A; González-Aguilar, Gustavo A.
Afiliação
  • Velásquez-Jiménez D; Centro de Investigación en Alimentación y Desarrollo A. C., Carretera Gustavo Enrique Astiazarán Rosas No. 46, Col. La Victoria, 83304 Hermosillo, Sonora, Mexico.
  • Corella-Salazar DA; Centro de Investigación en Alimentación y Desarrollo A. C., Carretera Gustavo Enrique Astiazarán Rosas No. 46, Col. La Victoria, 83304 Hermosillo, Sonora, Mexico.
  • Zuñiga-Martínez BS; Centro de Investigación en Alimentación y Desarrollo A. C., Carretera Gustavo Enrique Astiazarán Rosas No. 46, Col. La Victoria, 83304 Hermosillo, Sonora, Mexico.
  • Domínguez-Avila JA; Cátedras CONACYT-Centro de Investigación en Alimentación y Desarrollo A. C., Carretera Gustavo Enrique Astiazarán Rosas No. 46, Col. La Victoria, 83304 Hermosillo, Sonora, Mexico. abrahamdominguez9@gmail.com.
  • Montiel-Herrera M; Departamento de Medicina y Ciencias de la Salud, Universidad de Sonora, 83000 Hermosillo, Sonora, Mexico.
  • Salazar-López NJ; Centro de Investigación en Alimentación y Desarrollo A. C., Carretera Gustavo Enrique Astiazarán Rosas No. 46, Col. La Victoria, 83304 Hermosillo, Sonora, Mexico.
  • Rodrigo-Garcia J; Universidad Autónoma de Baja California, Facultad de Medicina de Mexicali, Dr. Humberto Torres Sanginés S/N, Centro Cívico, Mexicali, Baja California 21000, Mexico.
  • Villegas-Ochoa MA; Instituto de Ciencias Biomédicas, Universidad Autónoma de Ciudad Juárez, Anillo Envolvente del Pronaf y Estocolmo s/n, 32310 Ciudad Juárez, Chihuahua, Mexico.
  • González-Aguilar GA; Centro de Investigación en Alimentación y Desarrollo A. C., Carretera Gustavo Enrique Astiazarán Rosas No. 46, Col. La Victoria, 83304 Hermosillo, Sonora, Mexico.
Food Funct ; 12(21): 10356-10369, 2021 Nov 01.
Article em En | MEDLINE | ID: mdl-34608925
The blood-brain barrier (BBB) is a physical structure whose main function is to strictly regulate access to circulating compounds into the central nervous system (CNS). Vegetable-derived phenolic compounds have been widely studied, with numerous epidemiologic and interventional studies confirming their health-related bioactivities across multiple cells, organs and models. Phenolics are non-essential xenobiotics, and should theoretically be unable to cross the BBB. The present work summarizes current experimental evidence that reveals that not only are phenolic compounds able to cross the BBB and bioaccumulate in the brain, but there is some stereoselectivity, which suggests the presence of specific transporters that allow them to reach the brain. Some molecules cross the BBB intact, while others do so only after being biotransformed or metabolized elsewhere. Once inside the CNS, they prevent or counter oxidative stress, which maintains the molecular, cellular, structural and functional integrity of the brain, and subsequently, overall human health.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fenóis / Barreira Hematoencefálica / Xenobióticos / Sistema Nervoso Central / Antioxidantes Limite: Animals / Humans Idioma: En Revista: Food Funct Ano de publicação: 2021 Tipo de documento: Article País de afiliação: México País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fenóis / Barreira Hematoencefálica / Xenobióticos / Sistema Nervoso Central / Antioxidantes Limite: Animals / Humans Idioma: En Revista: Food Funct Ano de publicação: 2021 Tipo de documento: Article País de afiliação: México País de publicação: Reino Unido