Emerging immune and cell death mechanisms in stroke: Saponins as therapeutic candidates.
Brain Behav Immun Health
; 9: 100152, 2020 Dec.
Article
em En
| MEDLINE
| ID: mdl-34589895
The complexity of the ischemic cascade is based on the integrated crosstalk of every cell type in the neurovascular unit. Depending on the features of the ischemic insult, several cell death mechanisms are triggered, such as apoptosis, necroptosis, ferroptosis/oxytosis, ETosis or pyroptosis, leading to reactive astrogliosis. However, emerging evidence demonstrates a dual role for the immune system in stroke pathophysiology, where it exerts both detrimental and also beneficial functions. In this review, we discuss the relevance of several cell death modalities and the dual role of the immune system in stroke pathophysiology. We also provide an overview of some emerging immunomodulatory therapeutic strategies, amongst which saponins, which are promising candidates that exert multiple pharmacological effects.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Brain Behav Immun Health
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Cuba
País de publicação:
Estados Unidos