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Antifungal Activity of Extracts, Fractions, and Constituents from Coccoloba cowellii Leaves.
Méndez, Daniel; Escalona-Arranz, Julio C; Pérez, Enrique Molina; Foubert, Kenn; Matheeussen, An; Tuenter, Emmy; Cuypers, Ann; Cos, Paul; Pieters, Luc.
Afiliação
  • Méndez D; Chemistry Department, Faculty of Applied Sciences, University of Camagüey, Carretera de Circunvalación Km 5½, Camagüey 74650, Cuba.
  • Escalona-Arranz JC; Pharmacy Department, Faculty of Natural and Exact Sciences, Universidad de Oriente, Avenida Patricio Lumumba s/n, Santiago de Cuba 90500, Cuba.
  • Pérez EM; Chemistry Department, Faculty of Applied Sciences, University of Camagüey, Carretera de Circunvalación Km 5½, Camagüey 74650, Cuba.
  • Foubert K; Natural Products & Food Research and Analysis (NatuRA), Department of Pharmaceutical Sciences, University of Antwerp, Universiteitsplein 1, BE-2610 Antwerp, Belgium.
  • Matheeussen A; Laboratory of Microbiology, Parasitology and Hygiene (LMPH), Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Universiteitsplein 1, BE-2610 Antwerp, Belgium.
  • Tuenter E; Natural Products & Food Research and Analysis (NatuRA), Department of Pharmaceutical Sciences, University of Antwerp, Universiteitsplein 1, BE-2610 Antwerp, Belgium.
  • Cuypers A; Centre for Environmental Sciences, Campus Diepenbeek, Hasselt University, Agoralaan Building D, BE-3590 Diepenbeek, Belgium.
  • Cos P; Laboratory of Microbiology, Parasitology and Hygiene (LMPH), Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Universiteitsplein 1, BE-2610 Antwerp, Belgium.
  • Pieters L; Natural Products & Food Research and Analysis (NatuRA), Department of Pharmaceutical Sciences, University of Antwerp, Universiteitsplein 1, BE-2610 Antwerp, Belgium.
Pharmaceuticals (Basel) ; 14(9)2021 Sep 10.
Article em En | MEDLINE | ID: mdl-34577616
Coccoloba cowellii Britton (Polygonaceae, order Caryophyllales) is an endemic and critically endangered plant species that only grows in the municipality of Camagüey, a province of Cuba. A preliminary investigation of its total methanolic extract led to the discovery of promising antifungal activity. In this study, a bioassay-guided fractionation allowed the isolation of quercetin and four methoxyflavonoids: 3-O-methylquercetin, myricetin 3,3',4'-trimethyl ether, 6-methoxymyricetin 3,4'-dimethyl ether, and 6-methoxymyricetin 3,3',4'-trimethyl ether. The leaf extract, fractions, and compounds were tested against various fungi and showed strong in vitro antifungal activity against Cryptococcus neoformans and various Candida spp. with no cytotoxicity (CC50 > 64.0 µg/mL) on MRC-5 SV2 cells, determined by a resazurin assay. A Candida albicans SC5314 antibiofilm assay indicated that the antifungal activity of C. cowellii extracts and constituents is mainly targeted to planktonic cells. The total methanolic extract showed higher and broader activity compared with the fractions and mixture of compounds.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Pharmaceuticals (Basel) Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Cuba País de publicação: Suíça
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Pharmaceuticals (Basel) Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Cuba País de publicação: Suíça