The antioxidant effect of preischemic dexmedetomidine in a rat model: increased expression of Nrf2/HO-1 via the PKC pathway.

Park, Yong-Hee; Park, Hee-Pyoung; Kim, Eugene; Lee, Hannah; Hwang, Jung-Won; Jeon, Young-Tae; Lim, Young-Jin

Park, Yong-Hee; Park, Hee-Pyoung; Kim, Eugene; Lee, Hannah; Hwang, Jung-Won; Jeon, Young-Tae; Lim, Young-Jin.

Afiliação

Park YH; Chung-Ang University College of Medicine, Chung-Ang University Hospital, Department of Anesthesiology and Pain Medicine, Seoul, South Korea.
Park HP; Seoul National University College of Medicine, Seoul National University Hospital, Department of Anesthesiology and Pain Medicine, Seoul, South Korea.
Kim E; Hanyang University Medical Center, College of Medicine, Hanyang University, Department of Anesthesiology and Pain Medicine, Seoul, South Korea.
Lee H; Seoul National University College of Medicine, Seoul National University Hospital, Department of Anesthesiology and Pain Medicine, Seoul, South Korea.
Hwang JW; Seoul National University College of Medicine, Seoul National University Bundang Hospital, Department of Anesthesiology and Pain Medicine, Seongnam, South Korea.
Jeon YT; Seoul National University College of Medicine, Seoul National University Bundang Hospital, Department of Anesthesiology and Pain Medicine, Seongnam, South Korea.
Lim YJ; Seoul National University College of Medicine, Seoul National University Hospital, Department of Anesthesiology and Pain Medicine, Seoul, South Korea. Electronic address: limyjin@snu.ac.kr.

Braz J Anesthesiol ; 73(2): 177-185, 2023.

Article em En | MEDLINE | ID: mdl-34560114

Assuntos

Isquemia Encefálica; Dexmedetomidina; Ataque Isquêmico Transitório; Fármacos Neuroprotetores; Traumatismo por Reperfusão; Ratos; Animais; Heme Oxigenase-1/metabolismo; Heme Oxigenase-1/farmacologia; Antioxidantes/farmacologia; Antioxidantes/metabolismo; Proteína Quinase C/metabolismo; Proteína Quinase C/farmacologia; Fator 2 Relacionado a NF-E2/metabolismo; Fator 2 Relacionado a NF-E2/farmacologia; Dexmedetomidina/farmacologia; Ratos Sprague-Dawley; Estresse Oxidativo; Fármacos Neuroprotetores/farmacologia; Traumatismo por Reperfusão/prevenção & controle

Palavras-chave

Antioxidant; Cerebral ischemia; Dexmedetomidine; Nuclear factor erythroid 2-related factor; Protein kinase C

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Traumatismo por Reperfusão / Isquemia Encefálica / Ataque Isquêmico Transitório / Fármacos Neuroprotetores / Dexmedetomidina Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Braz J Anesthesiol Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Coréia do Sul País de publicação: Brasil

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