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Interkingdom Comparison of Threonine Metabolism for Stem Cell Maintenance in Plants and Animals.
Sahoo, Debee Prasad; Van Winkle, Lon J; Díaz de la Garza, Rocío I; Dubrovsky, Joseph G.
Afiliação
  • Sahoo DP; Departamento de Biología Molecular de Plantas, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Cuernavaca, Mexico.
  • Van Winkle LJ; Department of Biochemistry, Midwestern University, Downers Grove, IL, United States.
  • Díaz de la Garza RI; Department of Medical Humanities, Rocky Vista University, Parker, CO, United States.
  • Dubrovsky JG; Tecnologico de Monterrey, Escuela de Ingeniería y Ciencias, Monterrey, Mexico.
Front Cell Dev Biol ; 9: 672545, 2021.
Article em En | MEDLINE | ID: mdl-34557481
In multicellular organisms, tissue generation, maintenance, and homeostasis depend on stem cells. Cellular metabolic status is an essential component of different differentiated states, from stem to fully differentiated cells. Threonine (Thr) metabolism has emerged as a critical factor required to maintain pluripotent/multipotent stem cells in both plants and animals. Thus, both kingdoms conserved or converged upon this fundamental feature of stem cell function. Here, we examine similarities and differences in Thr metabolism-dependent mechanisms supporting stem cell maintenance in these two kingdoms. We then consider common features of Thr metabolism in stem cell maintenance and predict and speculate that some knowledge about Thr metabolism and its role in stem cell function in one kingdom may apply to the other. Finally, we outline future research directions to explore these hypotheses.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Revista: Front Cell Dev Biol Ano de publicação: 2021 Tipo de documento: Article País de afiliação: México País de publicação: Suíça
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Revista: Front Cell Dev Biol Ano de publicação: 2021 Tipo de documento: Article País de afiliação: México País de publicação: Suíça