Your browser doesn't support javascript.
loading
Dysregulated N6-methyladenosine (m6A) processing in hepatocellular carcinoma.
Wang, Yue-Fan; Ge, Chun-Mei; Yin, Hao-Zan; Dai, Zhi-Hui; Dong, Jun-Peng; Ji, Man; Yang, Fu.
Afiliação
  • Wang YF; The Department of Medical Genetics, Naval Medical University, Shanghai, 200433, China.. Electronic address: wangyuefan2015@163.com.
  • Ge CM; The Department of Medical Genetics, Naval Medical University, Shanghai, 200433, China.. Electronic address: CM-Ge@outlook.com.
  • Yin HZ; The Department of Medical Genetics, Naval Medical University, Shanghai, 200433, China.. Electronic address: ext512@126.com.
  • Dai ZH; The Department of Medical Genetics, Naval Medical University, Shanghai, 200433, China.. Electronic address: lh_zhihuidai@163.com.
  • Dong JP; The Department of Medical Genetics, Naval Medical University, Shanghai, 200433, China.. Electronic address: Dr_dongjunnian@163.com.
  • Ji M; The Department of Medical Genetics, Naval Medical University, Shanghai, 200433, China.. Electronic address: 1328576505@qq.com.
  • Yang F; The Department of Medical Genetics, Naval Medical University, Shanghai, 200433, China.. Electronic address: yangfusq1997@smmu.edu.cn.
Ann Hepatol ; 25: 100538, 2021.
Article em En | MEDLINE | ID: mdl-34555511
N6-methyladenosine (m6A) is the most thoroughly studied type of internal RNA modification, as this epigenetic modification is the most abundant in eukaryotic RNAs to date. This modification occurs in various types of RNAs and plays significant roles in dominant RNA-related processes, such as translation, splicing, export and degradation. These processes are catalyzed by three types of prominent enzymes: writers, erasers and readers. Increasing evidence has shown that m6A modification is vital for the regulation of gene expression, carcinogenesis, tumor progression and other abnormal changes, and recent studies have shown that m6A is important in the development of hepatocellular carcinoma (HCC). Herein, we summarize the nature and regulatory mechanisms of m6A modification, including its role in the pathogenesis of HCC and related chronic liver diseases. We also highlight the clinical significance and future strategies involving RNA m6A modifications in HCC.
Assuntos
Palavras-chave
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Adenosina / Carcinoma Hepatocelular / Neoplasias Hepáticas Limite: Humans Idioma: En Revista: Ann Hepatol Assunto da revista: GASTROENTEROLOGIA Ano de publicação: 2021 Tipo de documento: Article País de publicação: México
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Adenosina / Carcinoma Hepatocelular / Neoplasias Hepáticas Limite: Humans Idioma: En Revista: Ann Hepatol Assunto da revista: GASTROENTEROLOGIA Ano de publicação: 2021 Tipo de documento: Article País de publicação: México