Your browser doesn't support javascript.
loading
Does treatment with dutasteride or finasteride has impact on renal morphology? Experimental study.
Silva, Marcello Henrique Araújo da; Estrada, João Henrique Duque; Gregório, Bianca Martins; Sampaio, Francisco José Barcellos; Souza, Diogo Benchimol de.
Afiliação
  • Silva MHAD; MSc. Urogenital Research Unit - Universidade do Estado do Rio de Janeiro - Rio de Janeiro (RJ), Brazil.
  • Estrada JHD; MD. Urogenital Research Unit - Universidade do Estado do Rio de Janeiro (UERJ) - Rio de Janeiro (RJ), Brazil.
  • Gregório BM; PhD. Urogenital Research Unit - Universidade do Estado do Rio de Janeiro (UERJ) - Rio de Janeiro (RJ), Brazil.
  • Sampaio FJB; PhD. Urogenital Research Unit - Universidade do Estado do Rio de Janeiro (UERJ) - Rio de Janeiro (RJ), Brazil.
  • Souza DB; PhD. Urogenital Research Unit - Universidade do Estado do Rio de Janeiro (UERJ) - Rio de Janeiro (RJ), Brazil.
Acta Cir Bras ; 36(7): e360703, 2021.
Article em En | MEDLINE | ID: mdl-34550196
PURPOSE: To investigate whether renal modifications occur following treatment with dutasteride or finasteride. METHODS: Twenty-four male rats were divided into three groups: control (that received distilled water), dutasteride (0.5 mg/kg/day), and finasteride (5 mg/kg/day) groups. All administrations were given by gavage for 40 consecutive days. After inducing euthanasia, blood was collected for urea and creatinine analyses, and both the kidneys were collected for stereological analyses of kidney morphology. RESULTS: Serum urea and creatinine levels were increased in both the finasteride and the dutasteride groups compared with those in the control group. In addition, kidney weight, kidney volume, cortical volume, glomerular volumetric density, and mean glomerular volume were reduced in both treatment groups. Finally, the number of glomeruli per kidney was reduced by 26.8% in the finasteride group and by 51.6% in the dutasteride group compared with that in the control group. CONCLUSIONS: The 5-ARIs finasteride and dutasteride promoted morphological and functional damages in rat kidneys. In addition, rats in the dutasteride group showed more severe renal modifications than those in the finasteride group.
Assuntos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Finasterida / Inibidores de 5-alfa Redutase Limite: Animals Idioma: En Revista: Acta Cir Bras Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Finasterida / Inibidores de 5-alfa Redutase Limite: Animals Idioma: En Revista: Acta Cir Bras Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil