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Biotic stress caused by in vitro co-inoculation enhances the expression of acetylcholinesterase inhibitors by fungi.
de Oliveira, Geane Pereira; Barreto, Debora Luiza Costa; Ramalho Silva, Mauro; Augusti, Rodinei; Evódio Marriel, Ivanildo; Gomes de Paula Lana, Ubiraci; Takahashi, Jacqueline Aparecida.
Afiliação
  • de Oliveira GP; Department of Chemistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
  • Barreto DLC; Department of Chemistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
  • Ramalho Silva M; Department of Food Science, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
  • Augusti R; Department of Chemistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
  • Evódio Marriel I; National Center of Corn and Sorghum Research, Empresa Brasileira de Pesquisa Agropecuária, Sete Lagoas, Brazil.
  • Gomes de Paula Lana U; National Center of Corn and Sorghum Research, Empresa Brasileira de Pesquisa Agropecuária, Sete Lagoas, Brazil.
  • Takahashi JA; Department of Chemistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Nat Prod Res ; 36(16): 4266-4270, 2022 Aug.
Article em En | MEDLINE | ID: mdl-34542370
Fungi are an inexhaustible source of bioactive metabolites that can be driven to find medicines for chronic diseases, as Alzheimer's disease. In the present work, five species of soil-originated fungi (Aspergillus chevalieri, Clonostachys rogersoniana, Fusarium nygamai, Penicillium sp., and Talaromyces calidicanius) were submitted to mutual biotic stress aiming at activating the expression of metabolites capable of inhibiting the enzyme acetylcholinesterase. HPLC profiles showed that the in vitro biotic stress triggered the biosynthesis of metabolite-mediated defense responses. Five compounds present in the complex co-culture matrix were identified by Paper Spray Mass Spectrometry (PS-MS). The approach enhanced the biosynthesis of acetylcholinesterase inhibitors (up to 99.6% inhibition) in comparison with the individual cultures. The mutual biotic stress between T. calidicanius and A. Chevalieri led to the biosynthesis of a pool of metabolites statistically as efficient as serine (p < 0.05), the positive control used in the experiments (99.6 and 99.1% inhibition, respectively).
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Penicillium / Inibidores da Colinesterase Idioma: En Revista: Nat Prod Res Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Penicillium / Inibidores da Colinesterase Idioma: En Revista: Nat Prod Res Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido