Your browser doesn't support javascript.
loading
Gestational Weight Gain Influences the Adipokine-Oxidative Stress Association during Pregnancy.
Solis Paredes, Juan Mario; Perichart Perera, Otilia; Montoya Estrada, Araceli; Reyes Muñoz, Enrique; Espino Y Sosa, Salvador; Ortega Castillo, Veronica; Medina Bastidas, Diana; Tolentino Dolores, Maricruz; Sanchez Martinez, Maribel; Nava Salazar, Sonia; Estrada Gutierrez, Guadalupe.
Afiliação
  • Solis Paredes JM; Department of Human Genetics and Genomics, Instituto Nacional de Perinatologia, Mexico City, Mexico.
  • Perichart Perera O; Instituto Nacional de Perinatologia, Nutrition and Bioprogramming Coordination, Mexico City, Mexico.
  • Montoya Estrada A; Instituto Nacional de Perinatologia, Coordination of Gynecological and Perinatal Endocrinology, Mexico City, Mexico.
  • Reyes Muñoz E; Instituto Nacional de Perinatologia, Coordination of Gynecological and Perinatal Endocrinology, Mexico City, Mexico.
  • Espino Y Sosa S; Instituto Nacional de Perinatologia, Clinical Research Branch, Mexico City, Mexico.
  • Ortega Castillo V; Department of Obstetrics, Instituto Nacional de Perinatologia, Mexico City, Mexico.
  • Medina Bastidas D; Instituto Nacional de Perinatologia- Facultad de Quimica-UNAM, Unidad de Investigación en Reproducción Humana, Mexico City, Mexico.
  • Tolentino Dolores M; Instituto Nacional de Perinatologia, Nutrition and Bioprogramming Coordination, Mexico City, Mexico.
  • Sanchez Martinez M; Department of Inmunobiochemistry, Instituto Nacional de Perinatologia, Mexico City, Mexico.
  • Nava Salazar S; Department of Inmunobiochemistry, Instituto Nacional de Perinatologia, Mexico City, Mexico.
  • Estrada Gutierrez G; Research Division, Instituto Nacional de Perinatologia, Mexico City, Mexico.
Obes Facts ; 14(6): 604-612, 2021.
Article em En | MEDLINE | ID: mdl-34535612
INTRODUCTION AND OBJECTIVE: The weight gained during pregnancy could determine the immediate and future health of the mother-child dyad. Excessive gestational weight gain (EGWG) due to abnormal adipose tissue (AT) accumulation is strongly associated with adverse perinatal outcomes as gestational diabetes, macrosomia, obesity, and hypertension further in life. Dysregulation of adipokine, AT dysfunction, and an imbalance in the prooxidant-antioxidant systems are critical features in altered AT accumulation. This study was aimed to investigate the association between adipokines and oxidative stress markers in pregnant women and the influence of the GWG on this association. METHODS: Maternal blood samples were obtained in the third trimester of pregnancy (n = 74) and serum adipokines (adiponectin, leptin, and resistin), oxidative damage markers: 8-oxo-2'-deoxyguanosine (8-oxodG), lipohydroperoxides (LOOH), malondialdehyde (MDA), and carbonylated proteins (CP), and glucose a metabolic marker were measured. RESULTS: Women with EGWG had low adiponectin levels than women with adequate weight gain (AWG) or insufficient weight gain (IWG). Multiple linear regression models revealed a positive association between adiponectin and 8-oxodG in women with AWG (B = 1.09, 95% CI: 164-222, p = 0.027) and IWG (B = 0.860, 95% CI: 0.199-1.52, p = 0.013) but not in women with EGWG. In women with EGWG, leptin was positively associated with LOOH (p = 0.018), MDA (p = 0.005), and CP (p = 0.010) oxidative markers. CONCLUSION: Our findings suggest that concurrent mechanisms regulate adipokine production and oxidative stress in pregnant women and that this regulation is influenced by GWG, probably due to an excessive AT accumulation.
Assuntos
Palavras-chave
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ganho de Peso na Gestação Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Female / Humans / Pregnancy Idioma: En Revista: Obes Facts Assunto da revista: METABOLISMO Ano de publicação: 2021 Tipo de documento: Article País de afiliação: México País de publicação: Suíça
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ganho de Peso na Gestação Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Female / Humans / Pregnancy Idioma: En Revista: Obes Facts Assunto da revista: METABOLISMO Ano de publicação: 2021 Tipo de documento: Article País de afiliação: México País de publicação: Suíça