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Effect of dexamethasone on experimental enteritis produced by Giardia lamblia in a Meriones unguiculatus model.
Amaral, Rhuana S; Freitas, Joice F; Ribeiro, Mayana R S; Cara Machado, Denise C; Rocha, Fernanda F; Teixeira, Marcia C A; Cardoso, Valbert N; Andrade, Maria E R; Vilela Silva, César A; Caliari, Marcelo V; Gomes, Maria A.
Afiliação
  • Amaral RS; Department of Parasitology, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
  • Freitas JF; Department of Parasitology, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
  • Ribeiro MRS; Department of Parasitology, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
  • Cara Machado DC; Department of Morphology, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
  • Rocha FF; Department of Parasitology, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
  • Teixeira MCA; Department of Clinical and Toxicological Analysis, Pharmacy College, Universidade Federal da Bahia, Salvador, Brazil.
  • Cardoso VN; Department of Clinical and Toxicological Analysis, Pharmacy College, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
  • Andrade MER; Department of Clinical and Toxicological Analysis, Pharmacy College, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
  • Vilela Silva CA; Department of Pathology, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
  • Caliari MV; Department of Pathology, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
  • Gomes MA; Department of Parasitology, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil. Electronic address: mariahartmanni@yahoo.com.br.
Exp Parasitol ; 230: 108158, 2021 Nov.
Article em En | MEDLINE | ID: mdl-34534534
Our aim was to evaluate the impact of immunosuppression on the development of giardiasis. Thirty-six gerbils (4-6 weeks old) were distributed in four groups containing nine animals each: Control (CT); Control-Infected by Giardia lamblia (CTIn), Immunosuppressed (IS), and Immunosuppressed-Infected by G. lamblia (ISIn). Animals in the IS and ISIn groups received intramuscular dexamethasone solution for 25 days. On the 11th day, the animals in the CTIn and ISIn groups were inoculated with G. lamblia. After 14 days of infection, the 25th day of the experiment, all groups were euthanized. Four hours after euthanasia, the intestinal permeability was evaluated and sections of the duodenum and spleen were harvested for morphometric and histopathological analyses. Immunosuppressed groups showed a significant increase in intestinal permeability compared to control and infected groups. Considering that the infection can become chronic in immunosuppressed groups, we should be alert to the possibilities of chronic inflammatory changes, both locally and systemically, due to the loss of the intestinal barrier. Lesions were observed in the duodenal mucosa of the gerbils of the CTIn group, with reduced villi size, crypt hyperplasia, edema, and the presence of inflammatory infiltrate in the lamina propria. In the ISIn group, we observed no inflammation, long and intact villi, and a significant increase in the area of intestinal mucins, despite the large number of trophozoites identified. Our results suggest that exacerbation of the immune response has a direct relationship with the appearance of lesions during enteritis produced by G. lamblia in the assessed model.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Dexametasona / Giardíase / Enterite / Glucocorticoides Limite: Animals Idioma: En Revista: Exp Parasitol Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Dexametasona / Giardíase / Enterite / Glucocorticoides Limite: Animals Idioma: En Revista: Exp Parasitol Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos