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Evaluation of acute and subacute toxicity of ethanolic extract and fraction of alkaloids from bark of Aspidosperma nitidum in mice.
Brígido, Heliton Patrick Cordovil; Varela, Everton Luiz Pompeu; Gomes, Antônio Rafael Quadros; Bastos, Mirian Letícia Carmo; de Oliveira Feitosa, Andre; do Rosário Marinho, Andrey Moacir; Carneiro, Liliane Almeida; Coelho-Ferreira, Márlia Regina; Dolabela, Maria Fâni; Percário, Sandro.
Afiliação
  • Brígido HPC; Post-graduate Program in Pharmaceutical Innovation, Institute of Health Sciences, Federal University of Pará, Belém, PA, Brazil.
  • Varela ELP; Post-graduate Program in Biodiversity and Biotechnology (BIONORTE), Institute of Biological Sciences, Federal University of Pará, Belém, PA, Brazil.
  • Gomes ARQ; Oxidative Stress Research Laboratory, Institute of Biological Sciences, Federal University of Pará, Av. Augusto Corrêa, 01, Belém, PA, 66075-110, Brazil.
  • Bastos MLC; Post-graduate Program in Pharmaceutical Innovation, Institute of Health Sciences, Federal University of Pará, Belém, PA, Brazil.
  • de Oliveira Feitosa A; Oxidative Stress Research Laboratory, Institute of Biological Sciences, Federal University of Pará, Av. Augusto Corrêa, 01, Belém, PA, 66075-110, Brazil.
  • do Rosário Marinho AM; Post-graduate Program in Biodiversity and Biotechnology (BIONORTE), Institute of Biological Sciences, Federal University of Pará, Belém, PA, Brazil.
  • Carneiro LA; Post-graduate Program in Chemistry, Institute of Exact and Natural Sciences, Federal University of Pará, Belém, PA, Brazil.
  • Coelho-Ferreira MR; Post-graduate Program in Chemistry, Institute of Exact and Natural Sciences, Federal University of Pará, Belém, PA, Brazil.
  • Dolabela MF; National Primate Center, Evandro Chagas Institute, Ananindeua, PA, Brazil.
  • Percário S; Botany Coordination, Museu Paraense Emílio Goeldi, Ministério da Ciência, Tecnologia, Inovação e Comunicações, Belém, PA, Brazil.
Sci Rep ; 11(1): 18283, 2021 09 14.
Article em En | MEDLINE | ID: mdl-34521944
This study investigated the acute and subacute toxicity of the ethanolic extract (EE) and alkaloid fraction (FA) from A. nitidum. The EE was obtained from trunk bark with ethanol, FA was obtained from the fractionation of EE. To test the acute toxicity, mice were divided into four groups, and the negative controls received water or aqueous solution of dimethyl sulfoxide, whereas the others received EE or FA (2000 mg/kg, orally, single dose). The same controls were used in the subacute trial. However, the animals were treated for 28 days, and the dose used was 1000 mg/kg per day of EE and FA. Daily clinical evaluations of the animals were performed. At the end of the experiment, hematological, biochemical, and histopathological assessments (liver, lung, heart, and kidney) were performed. In the acute and subacute toxicity studies, mice treated with EE and FA did not show any clinical changes, there were no changes in weight gain, hematological and biochemical parameters compared to the control groups (p > 0.05). In the histopathological examination, there was no abnormality in the organs of the treated animals. Therefore, EE and FA did not produce toxic effects in mice after acute and subacute treatment.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Extratos Vegetais / Aspidosperma / Casca de Planta / Alcaloides Limite: Animals Idioma: En Revista: Sci Rep Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Extratos Vegetais / Aspidosperma / Casca de Planta / Alcaloides Limite: Animals Idioma: En Revista: Sci Rep Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido