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Stereotactic body radiotherapy for early-stage non-small cell lung cancer: a multicentre study by the Oncologic Group for the Study of Lung Cancer (Spanish Radiation Oncology Society).
Samper Ots, P Mª; Vallejo Ocaña, C; Martin Martin, M; Celada Álvarez, F J; Farga Albiol, D; Almendros Blanco, P; Hernandez Machancoses, A; Rico Oses, M; Flamarique Andueza, S; Romero Ruperto, F; Maria Bueno, C; Amaya Escobar, E; Guerrero Gómez, L L; Couñago, F; Del Pino Alcántara, Mª; Ruiz Villar, Mª J; Monroy Antón, J L; Saez Bueno, P; Luna Tirado, J; Del Mar Puertas, Mª; Bobo, A; Diaz de Cerio Martínez, I; Gascon Costoso, N; Ferrer Albiach, C.
Afiliação
  • Samper Ots PM; Hospital Universitario Rey Juan Carlos, Móstoles, Spain. pisamot@gmail.com.
  • Vallejo Ocaña C; Hospital Universitario Ramón y Cajal, Madrid, Spain.
  • Martin Martin M; Hospital Universitario Ramón y Cajal, Madrid, Spain.
  • Celada Álvarez FJ; Hospital Universitario y Politécnico La Fe, Valencia, Spain.
  • Farga Albiol D; Hospital Universitario y Politécnico La Fe, Valencia, Spain.
  • Almendros Blanco P; Hospital General de Valencia, Valencia, Spain.
  • Hernandez Machancoses A; Hospital General de Valencia, Valencia, Spain.
  • Rico Oses M; Complejo Hospitalario de Navarra, Navarra, Spain.
  • Flamarique Andueza S; Complejo Hospitalario de Navarra, Navarra, Spain.
  • Romero Ruperto F; Hospital Universitario Reina Sofía, Córdoba, Spain.
  • Maria Bueno C; Hospital Universitario Reina Sofía, Córdoba, Spain.
  • Amaya Escobar E; Hospital Universitario Rey Juan Carlos, Móstoles, Spain.
  • Guerrero Gómez LL; Hospital La Luz Madrid Quironsalud Madrid, Madrid, Spain.
  • Couñago F; Hospital Universitario Quironsalud y Hospital La Luz Quironsalud, Madrid, Spain.
  • Del Pino Alcántara M; Hospital Universitario Clínico San Carlos, Madrid, Spain.
  • Ruiz Villar MJ; Hospital Universitario La Paz, Madrid, Spain.
  • Monroy Antón JL; Hospital Universitario de la Rivera, Alcira, Valencia, Spain.
  • Saez Bueno P; Hospital Universitario Central de la Defensa "Gómez Ulla", Madrid, Spain.
  • Luna Tirado J; Hospital Universitario Fundación Jiménez Díaz, Madrid, Spain.
  • Del Mar Puertas M; Hospital Universitario Miguel Servet, Zaragoza, Spain.
  • Bobo A; Hospital Ruber Internacional, Madrid, Spain.
  • Diaz de Cerio Martínez I; Hospital Universitario Marques de Valdecilla, Santander, Spain.
  • Gascon Costoso N; Hospital Universitario 12 de Octubre, Madrid, Spain.
  • Ferrer Albiach C; Complejo Hospitalario Castellón, Castellón, Spain.
Clin Transl Oncol ; 24(2): 342-349, 2022 Feb.
Article em En | MEDLINE | ID: mdl-34487307
PURPOSE/OBJECTIVE(S): Stereotactic body radiotherapy (SBRT) has become the standard of care for patients with medically inoperable early-stage non-small cell lung cancer (NSCLC) and for patients who refuse surgery. The aim of this study was to evaluate the effectiveness and safety of primary SBRT in patients with early-stage NSCLC. MATERIALS/METHODS: Retrospective multicenter study of 397 patients (416 primary lung tumours) treated with SBRT at 18 centres in Spain. 83.2% were men. The median age was 74.4 years. In 94.4% of cases, the tumour was inoperable. The pathological report was available in 54.6% of cases. SPSS vs 22.0. was used to perform all statistical analyses. RESULTS: Complete response was obtained in 53.6% of cases. Significant prognostic factors were standard CT planning (p = 0.014) and 4D cone beam CT (p = 0.000). Acute and chronic toxicity ≥ grade 3 was observed in 1.2% of cases. At a median follow-up of 30 months, local relapse was 9.6%, lymph node relapse 12.8%, distant metastasis 16.6%, and another lung tumour 11.5%. Complete response was the only significant prognostic factor for local relapse (p = 0.012) and distant metastasis (p = 0.001). The local relapse-free survival was 88.7%. The overall survival was 75.7%. The cancer-specific survival was 92.7%. The disease-free survival was 78.7%. CONCLUSION: SBRT is an effective and well-tolerated treatment option for patients with early-stage lung cancer who are not suitable for surgery. The most important prognostic factor for local and distant recurrence was complete response, which in our sample depended on the type of CT planning and the IGRT technique.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Radiocirurgia / Carcinoma Pulmonar de Células não Pequenas / Neoplasias Pulmonares Tipo de estudo: Observational_studies / Prognostic_studies Limite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Clin Transl Oncol Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Espanha País de publicação: Itália

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Radiocirurgia / Carcinoma Pulmonar de Células não Pequenas / Neoplasias Pulmonares Tipo de estudo: Observational_studies / Prognostic_studies Limite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Clin Transl Oncol Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Espanha País de publicação: Itália