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Wound healing process with different photobiomodulation therapy protocols to treat 5-FU-induced oral mucositis in hamsters.
Cotomacio, Claudia C; Calarga, Caio C; Yshikawa, Bianca K; Arana-Chavez, Victor E; Simões, Alyne.
Afiliação
  • Cotomacio CC; School of Dentistry, Paulista University (UNIP), Sao Paulo, SP, Brazil; Pediatric Oncology Institute/GRAACC (Support Group for Children and Adolescents with Cancer), Department of Dentistry, Sao Paulo, Brazil.
  • Calarga CC; Department of Biomaterials and Oral Biology, University of Sao Paulo, School of Dentistry, Sao Paulo, SP, Brazil.
  • Yshikawa BK; Department of Biomaterials and Oral Biology, University of Sao Paulo, School of Dentistry, Sao Paulo, SP, Brazil.
  • Arana-Chavez VE; Department of Biomaterials and Oral Biology, University of Sao Paulo, School of Dentistry, Sao Paulo, SP, Brazil.
  • Simões A; Department of Biomaterials and Oral Biology, University of Sao Paulo, School of Dentistry, Sao Paulo, SP, Brazil. Electronic address: lysimoes@usp.br.
Arch Oral Biol ; 131: 105250, 2021 Nov.
Article em En | MEDLINE | ID: mdl-34482219
OBJECTIVES: The aim of this study was to analyze the effects of three different Photobiomodulation Therapy (PBMT) protocols in the treatment of 5-fluorouracil-induced oral mucositis in hamsters. DESIGN: 60 hamsters were divided into five groups: group "C", which did not receive oral mucosa scratching, 5-fluorouracil (5-FU) or PBMT; group "Ch", which received anesthesia, superficial oral mucosa scratching and 5-FU (oral mucositis induction); and three groups that received oral mucositis induction and a PBMT protocol: groups ChLI, ChLII and ChLIII that received 0.24 J (one point), 1 J (one point) and 1.2 J (five points of 0.24 J) of energy, respectively. The laser equipment used had λ = 660 nm and 0.04 cm2 of spot area (0.226 cm diameter). The animals were euthanized on days 7 and 10 of the experiment, and their oral mucosas were removed for histological (light microscopy and collagen staining), immunohistochemical (NF-kB and TNF-α), and biochemical (TNF-α, NF-kB and hydroxyproline) analysis. RESULTS: Group ChLI (less energy), showed the most accelerated repair rates and a lower concentration of inflammatory biomarkers than group Ch. Comparing the three PBMT protocols for treatment of 5-FU-induced oral mucositis in hamsters, the one with low energy (0.24 J) showed better results, regarding reduction of inflammatory biomarkers and tissue repair, than the ones with higher energy (1 and 1.2 J).
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Estomatite / Terapia com Luz de Baixa Intensidade / Mucosite Tipo de estudo: Guideline Limite: Animals Idioma: En Revista: Arch Oral Biol Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Estomatite / Terapia com Luz de Baixa Intensidade / Mucosite Tipo de estudo: Guideline Limite: Animals Idioma: En Revista: Arch Oral Biol Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido