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Behavioral Health Diagnoses in Youth with Differences of Sex Development or Congenital Adrenal Hyperplasia Compared with Controls: A PEDSnet Study.
Sewell, Rachel; Buchanan, Cindy L; Davis, Shanlee; Christakis, Dimitri A; Dempsey, Amanda; Furniss, Anna; Kazak, Anne E; Kerlek, Anna J; Magnusen, Brianna; Pajor, Nathan M; Pyle, Laura; Pyle, Louise C; Razzaghi, Hanieh; Schwartz, Beth I; Vogiatzi, Maria G; Nokoff, Natalie J.
Afiliação
  • Sewell R; Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO.
  • Buchanan CL; Department of Psychiatry, University of Colorado Anschutz Medical Campus, Aurora, CO.
  • Davis S; Division of Endocrinology, Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO.
  • Christakis DA; Seattle Children's Research Institute, Center for Child Health, Behavior & Development, Seattle, WA.
  • Dempsey A; Merck and Co., Kenilworth, NJ.
  • Furniss A; University of Colorado Anschutz Medical Campus, Adult & Child Consortium for Health Outcomes Research & Delivery, Aurora, CO.
  • Kazak AE; Nemours Children's Health, Department of Pediatrics, Center for Healthcare Delivery Science and Thomas Jefferson University, Wilmington, DE.
  • Kerlek AJ; Department of Psychiatry and Behavioral Health, Nationwide Children's Hospital, Columbus, OH.
  • Magnusen B; Nationwide Children's Hospital, Institute for Informatics, Columbus, OH.
  • Pajor NM; Cincinnati Children's Hospital Medical Center, Division of Pulmonary Medicine and University of Cincinnati College of Medicine, Department of Pediatrics, Cincinnati, OH.
  • Pyle L; Division of Endocrinology, Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO.
  • Pyle LC; Division of Human Genetics, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA.
  • Razzaghi H; Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA.
  • Schwartz BI; Nemours Children's Health, Department of Pediatrics and Thomas Jefferson University, Department of Obstetrics and Gynecology, Wilmington, DE.
  • Vogiatzi MG; Division of Endocrinology and Diabetes, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA.
  • Nokoff NJ; Division of Endocrinology, Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO. Electronic address: Natalie.Nokoff@childrenscolorado.org.
J Pediatr ; 239: 175-181.e2, 2021 12.
Article em En | MEDLINE | ID: mdl-34461062
OBJECTIVE: To evaluate the odds of a behavioral health diagnosis among youth with differences of sex development (DSD) or congenital adrenal hyperplasia (CAH) compared with matched controls in the PEDSnet database. STUDY DESIGN: All youth with a diagnosis of DSD (n = 1216) or CAH (n = 1647) and at least 1 outpatient encounter were extracted from the PEDSnet database and propensity-score matched on 8 variables (1:4) with controls (n = 4864 and 6588, respectively) using multivariable logistic regression. The likelihood of having behavioral health diagnoses was examined using generalized estimating equations. RESULTS: Youth with DSD had higher odds of a behavioral health diagnosis (OR, 1.7; 95% CI, 1.4-2.1; P < .0001) and neurodevelopmental diagnosis (OR, 1.7; 95% CI, 1.4, 2.0; P < .0001) compared with matched controls. Youth with CAH did not have an increased odds of a behavioral health diagnosis (OR, 1.0; 95% CI, 0.9, 1.1; P = .9) compared with matched controls but did have higher odds of developmental delay (OR, 1.8; 95% CI, 1.4, 2.4; P < .0001). CONCLUSIONS: Youth with DSD diagnosis have higher odds of a behavioral health or neurodevelopmental diagnosis compared with matched controls. Youth with CAH have higher odds of developmental delay, highlighting the need for screening in both groups.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transtornos do Desenvolvimento Sexual / Hiperplasia Suprarrenal Congênita / Transtornos Mentais Tipo de estudo: Diagnostic_studies / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male / Newborn Idioma: En Revista: J Pediatr Ano de publicação: 2021 Tipo de documento: Article País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transtornos do Desenvolvimento Sexual / Hiperplasia Suprarrenal Congênita / Transtornos Mentais Tipo de estudo: Diagnostic_studies / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male / Newborn Idioma: En Revista: J Pediatr Ano de publicação: 2021 Tipo de documento: Article País de publicação: Estados Unidos