[Electrocorticographic changes in acute experimental hepatic insufficiency]. / Estudo das alterações eletrocorticográficas na insuficiência hepática aguda experimental.
Arq Gastroenterol
; 23(4): 229-35, 1986.
Article
em Pt
| MEDLINE
| ID: mdl-3442509
The aim of this study was to test the application and value of electrocorticography (ECG) in the early diagnosis and characterization of electrocorticograms changes on experimental fulminant hepatic failure (FHF). Our material was composed of two groups of guinea pigs: a) ethanolamine group--42 animals with FHF induced by intrabiliary injection of 2.5 ml of monoethanolamine oleate; b) control group--10 animals submitted to intrabiliary injection of 2.5 ml of saline. Electrocorticograms recordings were taken in both groups with the electrodes implanted on the parieto-occipital regions of the skull. The hepatic failure was characterized by clinical manifestations, serum biochemical tests and histopathological findings. In the early hepatic coma the electrocorticograms could not be unequivocally distinguished from normal pattern, and alpha rhythm was recognizable in most animals. With further deterioration of the clinical condition the tracing showed progressive slowness of the normal rhythm, increased voltage and triphasic waves followed by suppression of electrical activity preceding the animal death. The electrocorticography was not suitable for the early diagnosis of hepatic coma, since the ECG alterations became evident only in overt coma. However the method could be useful for the characterization of cerebral disorders and the study of the pathogenesis of fulminant hepatic failure.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Encefalopatia Hepática
/
Eletroencefalografia
Tipo de estudo:
Screening_studies
Limite:
Animals
Idioma:
Pt
Revista:
Arq Gastroenterol
Ano de publicação:
1986
Tipo de documento:
Article
País de publicação:
Brasil