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The Heparan Sulfate Binding Peptide in Tumor Progression of Triple-Negative Breast Cancer.
Melo, Carina Mucciolo; Wang, Huawei; Fujimura, Ken; Strnadel, Jan; Meneghetti, Maria Cecília Zorél; Nader, Helena Bonciani; Klemke, Richard L; Pinhal, Maria Aparecida Silva.
Afiliação
  • Melo CM; Department of Biochemistry/Molecular Biology, Universidade Federal de São Paulo, São Paulo, Brazil.
  • Wang H; Department of Biochemistry, Faculdade de Medicina do ABC, Santo André, Brazil.
  • Fujimura K; Department of Pathology, School of Medicine, University of California San Diego, La Jolla, CA, United States.
  • Strnadel J; Department of Pathology, School of Medicine, University of California San Diego, La Jolla, CA, United States.
  • Meneghetti MCZ; Department of Molecular Medicine, Biomedical Center Martin, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovakia.
  • Nader HB; Department of Biochemistry/Molecular Biology, Universidade Federal de São Paulo, São Paulo, Brazil.
  • Klemke RL; Department of Biochemistry/Molecular Biology, Universidade Federal de São Paulo, São Paulo, Brazil.
  • Pinhal MAS; Department of Pathology, School of Medicine, University of California San Diego, La Jolla, CA, United States.
Front Oncol ; 11: 697626, 2021.
Article em En | MEDLINE | ID: mdl-34422650
Angiogenesis is the formation of new vessels from pre-existing vasculature. The heparan sulfate chains from endothelial cell proteoglycans interact with the major angiogenic factors, regulating blood vessels´ formation. Since the FDA´s first approval, anti-angiogenic therapy has shown tumor progression inhibition and increased patient survival. Previous work in our group has selected an HS-binding peptide using a phage display system. Therefore, we investigated the effect of the selected peptide in angiogenesis and tumor progression. The HS-binding peptide showed a higher affinity for heparin N-sulfated. The HS-binding peptide was able to inhibit the proliferation of human endothelial umbilical cord cells (HUVEC) by modulation of FGF-2. It was verified a significant decrease in the tube formation of human endothelial cells and capillary formation of mice aorta treated with HS-binding peptide. HS-binding peptide also inhibited the formation of sub-intestinal blood vessels in zebrafish embryos. Additionally, in zebrafish embryos, the tumor size decreased after treatment with HS-binding peptide.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Front Oncol Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Front Oncol Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça