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Post-hematopoietic stem cell transplant squamous cell carcinoma in patients with Fanconi anemia: a dreadful enemy.
Murillo-Sanjuán, L; Balmaña, J; de Pablo García-Cuenca, A; Lorente Guerrero, J; Uria Oficialdegui, M L; Carrasco, E; Diaz-de-Heredia, C.
Afiliação
  • Murillo-Sanjuán L; Department of Pediatric Oncology and Hematology, Hospital Universitari Vall d'Hebron, Barcelona, Spain.
  • Balmaña J; Department of Medical Oncology and Hereditary Cancer Genetics Group, Vall d'Hebron Institute of Oncology (VHIO), Hospital Universitari Vall d'Hebron, Barcelona, Spain.
  • de Pablo García-Cuenca A; Department of Oral and Maxillofacial Surgery, Hospital Universitari Vall d'Hebron, Barcelona, Spain.
  • Lorente Guerrero J; Department of Otorhinolaryngology, Hospital Universitari Vall d'Hebron, Barcelona, Spain.
  • Uria Oficialdegui ML; Department of Pediatric Oncology and Hematology, Hospital Universitari Vall d'Hebron, Barcelona, Spain.
  • Carrasco E; Department of Medical Oncology and Hereditary Cancer Genetics Group, Vall d'Hebron Institute of Oncology (VHIO), Hospital Universitari Vall d'Hebron, Barcelona, Spain.
  • Diaz-de-Heredia C; Department of Pediatric Oncology and Hematology, Hospital Universitari Vall d'Hebron, Barcelona, Spain. crdiaz@vhebron.net.
Clin Transl Oncol ; 24(2): 388-392, 2022 Feb.
Article em En | MEDLINE | ID: mdl-34417960
INTRODUCTION: Hematopoietic stem cell transplantation (HSCT) is a curative option for patients with Fanconi anemia (FA) and hematological manifestations but it does not prevent solid tumors, especially squamous cell carcinomas (SCC). METHODS: Retrospective study in 22 FA patients who had received HSCT and had been followed up beyond 2 years after HSCT. RESULTS: The median follow-up was 15 years. Six patients developed head-and-neck SCC after transplantation. The cumulative incidence of SCC at 15 and 30 years from the HSCT was 14.2% and 71.2%, respectively. One patient was diagnosed in stage IV and the rest, who were being followed up in cancer screening programs, in stage I. Treatment of SCC consisted of surgery in all patients; radiotherapy and chemotherapy were used in two patients and were poorly tolerated. CONCLUSION: FA patients have high risk of head-and-neck SCC. Multi-disciplinary programs for early cancer detection are of special relevance in these patients.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Complicações Pós-Operatórias / Carcinoma de Células Escamosas / Transplante de Células-Tronco Hematopoéticas / Anemia de Fanconi / Neoplasias de Cabeça e Pescoço Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male Idioma: En Revista: Clin Transl Oncol Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Espanha País de publicação: Itália
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Complicações Pós-Operatórias / Carcinoma de Células Escamosas / Transplante de Células-Tronco Hematopoéticas / Anemia de Fanconi / Neoplasias de Cabeça e Pescoço Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male Idioma: En Revista: Clin Transl Oncol Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Espanha País de publicação: Itália