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Human Eosinophils Reduce Viral Titer, Secrete IL-8, and Increase RIG-I Expression in Response to Influenza A H1N1 pdm09.
Flores-Torres, Armando S; Rendon, Adrian; Salinas-Carmona, Mario C; Salinas, Eva; Rosas-Taraco, Adrian G.
Afiliação
  • Flores-Torres AS; Department of Immunology, Faculty of Medicine, Universidad Autónoma de Nuevo León, Monterrey, Mexico.
  • Rendon A; Center of Research, Prevention and Treatment of Respiratory Diseases (CIPTIR), University Hospital, Universidad Autónoma de Nuevo León Monterrey, Mexico.
  • Salinas-Carmona MC; Department of Immunology, Faculty of Medicine, Universidad Autónoma de Nuevo León, Monterrey, Mexico.
  • Salinas E; Department of Microbiology, Center of Basic Science, Universidad Autónoma de Aguascalientes, Aguascalientes, Mexico.
  • Rosas-Taraco AG; Department of Immunology, Faculty of Medicine, Universidad Autónoma de Nuevo León, Monterrey, Mexico.
Viral Immunol ; 34(8): 573-578, 2021 10.
Article em En | MEDLINE | ID: mdl-34415814
Eosinophils participate in the immune response against many pathogens, including viruses. Since mouse eosinophils are susceptible to influenza A virus infection and possess antiviral activity, we evaluated the expression of sialic acid residues in human eosinophils and their response against influenza virus in vitro. We demonstrated that human eosinophils express α2,6- and α2,3-linked sialic acid, and drastically reduced influenza virus titer. After influenza virus exposure, eosinophils upregulated retinoic acid-inducible gene I (RIG-I) mRNA expression, but no other pattern recognition receptors. Finally, high concentrations of interleukin-8 (IL-8) were found in influenza virus-exposed eosinophil cultures. These data suggest that human eosinophils possess antiviral activity and may play a role in the innate immune response to influenza virus.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vírus da Influenza A / Influenza Humana / Vírus da Influenza A Subtipo H1N1 Limite: Humans Idioma: En Revista: Viral Immunol Assunto da revista: ALERGIA E IMUNOLOGIA / VIROLOGIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: México País de publicação: Estados Unidos
Texto completo
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XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vírus da Influenza A / Influenza Humana / Vírus da Influenza A Subtipo H1N1 Limite: Humans Idioma: En Revista: Viral Immunol Assunto da revista: ALERGIA E IMUNOLOGIA / VIROLOGIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: México País de publicação: Estados Unidos