Your browser doesn't support javascript.
loading
Reference values for the triglyceride to high-density lipoprotein ratio and its association with cardiometabolic diseases in a mixed adult population: The ELSA-Brasil study.
Lelis, Deborah de Farias; Calzavara, João Vitor S; Santos, Raul D; Sposito, Andrei C; Griep, Rosane Härter; Barreto, Sandhi Maria; Molina, Maria Del Carmen B; Schmidt, Maria Inês; Duncan, Bruce B; Bensenor, Isabella; Lotufo, Paulo Andrade; Mill, José Geraldo; Baldo, Marcelo Perim.
Afiliação
  • Lelis DF; Department of Pathophysiology, Montes Claros State University (UNIMONTES), Montes Claros, MG, Brazil.
  • Calzavara JVS; Department of Pathophysiology, Montes Claros State University (UNIMONTES), Montes Claros, MG, Brazil.
  • Santos RD; Lipid Clinic Heart Institute (Incor) University of São Paulo Medical School Hospital, São Paulo, Brazil.
  • Sposito AC; Cardiology Division, Faculty of Medical Sciences, State University of Campinas (Unicamp), Campinas, SP, Brazil.
  • Griep RH; Laboratory of Health and Environment Education, Oswaldo Cruz Institute, Rio de Janeiro, RJ, Brazil.
  • Barreto SM; Faculty of Medicine, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
  • Molina MDCB; Post Graduate Programme in Public Health, Federal University of Espírito Santo, Vitória, ES, Brazil.
  • Schmidt MI; School of Medicine and Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
  • Duncan BB; School of Medicine and Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
  • Bensenor I; Center for Clinical and Epidemiologic Research, University of São Paulo, São Paulo, SP, Brazil.
  • Lotufo PA; Center for Clinical and Epidemiologic Research, University of São Paulo, São Paulo, SP, Brazil.
  • Mill JG; Department of Physiological Sciences, Federal University of Espírito Santo, Vitória, ES, Brazil.
  • Baldo MP; Department of Pathophysiology, Montes Claros State University (UNIMONTES), Montes Claros, MG, Brazil. Electronic address: marcelobaldo@ymail.com.
J Clin Lipidol ; 15(5): 699-711, 2021.
Article em En | MEDLINE | ID: mdl-34389285
BACKGROUND: Among several lipid ratios available, the triglyceride/HDL-cholesterol (TG/HDL-C) may detect individuals at risk of cardiometabolic diseases. However, its reference values for different ethnicities are not well established. OBJECTIVE: To define sex- and ethnicity-specific reference values for TG/HDL-C ratio in a large sample of healthy multiethnic adults and test its association with cardiometabolic conditions. METHODS: An apparently healthy sample (n = 2,472), aged 35-74, free of major cardiovascular risk factors, was used to generate the reference values for the TG/HDL-C. Exclusion criteria were diabetes, elevated blood pressure, obesity, hypercholesterolemia, severe hypertriglyceridemia, and smoking history. Cut-offs based on the reference values were tested in the whole ELSA Brasil study (n = 13,245), stratified by sex and ethnicity, to identify cardiometabolic conditions. RESULTS: TG/HDL-C ratio was higher in men than women, and did not change significantly with age, regardless of sex and ethnicity. Also, black individuals showed lower levels of TG/HDL-C as compared to other ethnic groups. ROC curve showed that the cut-off based on the 75th percentile displayed better sensitivities and specificities for men and women, regardless of ethnicity. Also, the sex- and ethnicity-specific cut-offs based on the 75th percentile were significantly associated with all tested cardiometabolic conditions (hypertension, diabetes, obesity, metabolic syndrome, and insulin resistance). Also, we observed that the use of a single sex-specific cut-off (men: 2.6; women: 1.7) could be used for the different ethnicities with good reliability. CONCLUSION: The defined TG/HDL-C cut-offs (men: 2.6; women: 1.7) are reliable and showed good clinical applicability to detect cardiometabolic conditions in a multiethnic population.
Assuntos
Palavras-chave
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Triglicerídeos / Síndrome Metabólica / Lipoproteínas HDL Tipo de estudo: Etiology_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged País/Região como assunto: America do sul / Brasil Idioma: En Revista: J Clin Lipidol Assunto da revista: BIOQUIMICA / METABOLISMO Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Triglicerídeos / Síndrome Metabólica / Lipoproteínas HDL Tipo de estudo: Etiology_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged País/Região como assunto: America do sul / Brasil Idioma: En Revista: J Clin Lipidol Assunto da revista: BIOQUIMICA / METABOLISMO Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos