Dietary inflammatory index and its relationship with gut microbiota in individuals with intestinal constipation: a cross-sectional study.

Costa, Lorena M; Mendes, Marcela M; Oliveira, Amanda C; Magalhães, Kelly G; Shivappa, Nitin; Hebert, James R; da Costa, Teresa H M; Botelho, Patrícia B

Costa, Lorena M; Mendes, Marcela M; Oliveira, Amanda C; Magalhães, Kelly G; Shivappa, Nitin; Hebert, James R; da Costa, Teresa H M; Botelho, Patrícia B.

Afiliação

Costa LM; Department of Nutrition, Faculty of Health Sciences, University of Brasília, Brasília, Brazil.
Mendes MM; Department of Nutrition, Faculty of Health Sciences, University of Brasília, Brasília, Brazil.
Oliveira AC; Faculty of Nutrition, Federal University of Goias, Goiânia, GO, Brazil.
Magalhães KG; Laboratory of Immunology and Inflammation, University of Brasília, Brasília, DF, Brazil.
Shivappa N; Cancer Prevention and Control Program, University of South Carolina, Columbia, SC, USA.
Hebert JR; Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC, USA.
da Costa THM; Department of Nutrition, Connecting Health Innovations LLC, Columbia, SC, USA.
Botelho PB; Cancer Prevention and Control Program, University of South Carolina, Columbia, SC, USA.

Eur J Nutr ; 61(1): 341-355, 2022 Feb.

Article em En | MEDLINE | ID: mdl-34351455

RESUMO

OBJECTIVE: To determine whether there is an association between the inflammatory potential of the diet, measured by the dietary inflammatory index (DII®), and the composition of intestinal microbiota in adults with functional constipation (FC). METHODS: A cross-sectional study was carried out with 68 adults with FC. Energy-adjusted DII (E-DII) was calculated from data obtained from food surveys, serum inflammation markers were measured and the composition of the intestinal microbiota was evaluated using the 16S rRNA gene sequencing method. Participants were assigned into two groups: anti-inflammatory diet (AD: E-DII < 0) and pro-inflammatory diet (PD: E-DII ≥ 0). Associations of E-DII scores with microbial diversity and composition were examined using differences between the E-DII groups and linear and hierarchical regression. RESULTS: E- DII was inversely correlated with relative abundance of Hungatella spp. and Bacteroides fragilis and positively correlated with Bacteroides thetaiotaomicron and Bacteroides caccae (p < 0.05). B. fragilis was positively correlated with IL-10. The AD group had higher relative abundances for the genus Blautia and Hungatella, lower abundances of Bacteroides thetaiotamicron and Bacteroides spp. (p < 0.05), as well as higher frequency of evacuation (p = 0.02) and lower use of laxatives (p = 0.05). The AD group showed a reduction in the abundance of Desulfovibrio spp. and Butyrivibrio, Butyrivibrio crossotus, Bacteroides clarus, Bacteroides coprophilus and Bacteroides intestinalis (all p < 0.05). The greater abundance of Bacteroides clarus increased the individual's chance of performing a manual evacuation maneuver. CONCLUSION: Therefore, the results of this study demonstrated that the inflammatory potential of the diet is associated with the gut microbiota in individuals with FC.

Assuntos

Microbioma Gastrointestinal; Adulto; Constipação Intestinal; Estudos Transversais; Dieta; Humanos; Inflamação; RNA Ribossômico 16S/genética

Palavras-chave

Constipation; Diet; Dietary inflammatory index; Microbiota

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Microbioma Gastrointestinal Tipo de estudo: Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Adult / Humans Idioma: En Revista: Eur J Nutr Assunto da revista: CIENCIAS DA NUTRICAO Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Alemanha

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