Your browser doesn't support javascript.
loading
Evidence for antioxidant and anti-inflammatory potential of mango (Mangifera indica L.) in naproxen-induced gastric lesions in rat.
Ferreira Gomes, Carla Catiúscia; de Siqueira Oliveira, Luciana; Rodrigues, Delane C; Ribeiro, Paulo Riceli Vasconcelos; Canuto, Kirley Marques; Duarte, Antoniella Souza Gomes; Eça, Kaliana Sitonio; de Figueiredo, Raimundo Wilane.
Afiliação
  • Ferreira Gomes CC; Department of Food Engineering, Federal University of Ceara, Fortaleza, Brazil.
  • de Siqueira Oliveira L; Department of Food Engineering, Federal University of Ceara, Fortaleza, Brazil.
  • Rodrigues DC; Department of Food Engineering, Federal University of Ceara, Fortaleza, Brazil.
  • Ribeiro PRV; Embrapa Agroindústria Tropical, Fortaleza, Brazil.
  • Canuto KM; Embrapa Agroindústria Tropical, Fortaleza, Brazil.
  • Duarte ASG; Department of Physiology and Pharmacology, School of Medicine, Federal University of Ceara, Fortaleza, Brazil.
  • Eça KS; Department of Food Engineering, Federal University of Ceara, Fortaleza, Brazil.
  • de Figueiredo RW; Department of Food Engineering, Federal University of Ceara, Fortaleza, Brazil.
J Food Biochem ; 46(3): e13880, 2022 03.
Article em En | MEDLINE | ID: mdl-34350985
This study investigated the anti-inflammatory and antioxidant effects of hydroalcoholic extracts of mango peel and pulp on oxidative damage in a naproxen-induced gastric injury rat model. The extracts were assessed for antioxidant activity (ABTS and FRAP methods), and the phenolic profile was investigated with UPLC-QToF-MSE . Gastric damage was evaluated in vivo by assessing the membrane lipid peroxidation (malondialdehyde (MDA) content), myeloperoxidase (MPO) enzyme activity, and glutathione (GSH) content. Mango peel and pulp contained high contents of bioactive compounds, particularly phenolics (69.50-5.287.70 mg gallic acid equivalents/100 g), carotenoids (651.30-665.50 µg/100 g), and vitamin C (21.59-108.19 mg/100 g). UPLC-QToF-MSE analysis identified 17 phenol compounds, including gallotannins, glycosylated flavonoids, and xanthone. The hydroalcoholic extracts of mango peel and pulp (LPe and LPu, respectively) significantly reduced the MPO activity and MDA content. In addition to preventing naproxen-induced GSH decline, LPe (30 mg/kg) and LPu (10 mg/kg) restored its content to normal levels. LPe and LPu neutralized the oxidizing agents triggered by naproxen and reduced the severity of gastric lesions owing to their antioxidant properties.
Assuntos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Mangifera Limite: Animals Idioma: En Revista: J Food Biochem Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Mangifera Limite: Animals Idioma: En Revista: J Food Biochem Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos